Hydroxychloroquine (HCQ) enhances the anti-cancer activity of the histone deacetylase inhibitor, vorinostat (VOR), in pre-clinical models and early phase clinical studies of metastatic colorectal cancer (mCRC). Mechanisms could include autophagy inhibition, accumulation of ubiquitinated proteins, and subsequent tumor cell apoptosis. There is growing evidence that autophagy inhibition could lead...

Hydroxychloroquine (HCQ), a drug used to treat many diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), has limited reports documenting drug-induced myopathies side effect. This entity is underdiagnosed with unclear treatment interventions apart from discontinuing the offending drug. We report case of biopsy-proven hydroxychloroquine-induced myopathy in 35-year-ol...

Background: Hydroxychloroquine (HCQ), a useful treatment for chronic dermatologic or rheumatologic diseases, has recently gathered widespread attention as possible COVID-19 infection. However, its rare et severe neuropsychiatric side effects (NSE), such psychosis and suicidal tendencies, are poorly documented, especially in youths.

Clinical trials are investigating several agents as potential options for pre-exposure prophylaxis and post-exposure to prevent infection with COVID-19. A particular focus has been high risk groups including healthcare workers. Chloroquine (CQ) hydroxychloroquine (HCQ) the predominant in terms of numbers clinical listed on Clinicaltrials.gov.

The aim of this study was to develop an effective controlled drug delivery system based on alginate beads for the treatment autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). present describes systems control uses hydroxychloroquine (HCQ) by Ca-alginate beads. characterization techniques were employed evaluate physicochemical properties scanning electr...

BACKGROUND Osteoarthritis (OA) is a heterogeneous group of conditions with disturbed integrity of articular cartilage and changes in the underlying bone. The pathogenesis of OA is multifactorial and not just a disease of older people. Hydroxychloroquine (HCQ) is a disease-modifying anti-rheumatic drug (DMARD) typically used for the treatment of various rheumatic and dermatologic diseases. Three...

OBJECTIVE The use of disease modifying antirheumatic drugs (DMARD) for rheumatoid arthritis (RA) is predicated on the expected value of the treatment course. Most clinical data are generalized from randomized controlled trials (RCT), which may result in estimates that are discordant with clinical experience and cannot address the effects of sequence of drugs. We computed estimates of relative D...

Objective—To determine the eVect of intramuscular gold and oral hydroxychloroquine(HCQ) on the lipid profile of patients with rheumatoid arthritis (RA). Method—A prospective randomised clinical trial of 12 months’ duration was performed in 100 RA patients. Data on clinical and laboratory parameters of disease activity, and fasting serum lipid samples was collected at baseline and at three month...

Background: Chloroquine (CQ) and hydroxychloroquine (HCQ) have been employed in a huge range of indications, from autoimmune diseases (such as rheumatoid arthritis [RA], cutaneous lupus or systemic erythematosus [SLE]) to infectious ones (as malaria helminthiasis). 1 A newer purpose came upon the new coronavirus disease 2019 (COVID-19), where they seem be effective modulating immune response. C...