Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three ...

A Simple high-performance thin layer chromatography (HPTLC) method for separation and quantitative analysis of losartan potassium, amlodipine, and hydrochlorothiazide in bulk and in pharmaceutical formulations has been established and validated. After extraction with methanol, sample and standard solutions were applied to silica gel plates and developed with chloroform : methanol : acetone : fo...

A simple, rapid and precise HPLC method has been developed for the assay of hydrochlorothiazide in urine. The clean-up of the urine samples was carried out by solid-phase extraction using HLB cartridges. Extraction recovery was 94.00-100.28 %. HPLC separation was performed with isocratic elution on Hypersil BDS C18 column (100 x 4.0 mm I.D., 3 μm particle size) protected with appropriate guard ...

Recent study shows close relationship between hypertension and inflammation. The concentration of inflammatory mediators is increased in patients with essential hypertension. Angiotensin II (Ang II) may contribute to inflammatory process. Previous studies showed that individuals with essential hypertension had increased interleukin-1beta (IL-1β) secretion by peripheral blood mononuclear cells (...

Donckerwolcke, R. A., van Stekelenburg, G. J., and Tiddens, H. A. (1970). Archives of Disease in Childhood, 45, 774. The therapy of bicarbonate-losing renal tubular acidosis. A 2-year-old-girl with severe bicarbonate-losing renal tubular acidosis was treated successively with bicarbonate, THAM, and two diuretics, hydrochlorothiazide and frusemide. Only with hydrochlorothiazide was adequate corr...

Purpose: To develop a simple, sensitive and rapid reverse phase HPLC method for the simultaneous analysis of metoprolol succinate and hydrochlorothiazide in a solid dosage form. Methods: The drugs were analysed by a reverse phase C-18 column using 50mM di-sodium hydrogen phosphate:methanol:acetonitrile in a ratio of 525:225:250 as mobile phase. The flow rate was 1 ml/min and the compounds were ...

Thiazides were among the first drugs discovered to be associated with pancreatitis [8]. Although there are several thiazide diuretics currently available, chlorthalidone and hydrochlorothiazide have been the two most commonly used diuretics in major clinical trials [9]. Hydrochlorothiazide was approved by the Food and Drug Administration (FDA) in 1959 [10] and it continues to be the most popula...

Introduction: hydrochlorothiazide is a diuretic drug indicated for the continuoustreatment of hypertension. The presented as medicine in form tabletscontaining only one active agent or combined formulations with concentrationsof 12.5, 25 and 50 mg. mg dosage most widely used medical therapy.Therefore, considering incidence hypertension prolonged use drug, it isnecessary to determine quality tab...

A simple high-performance thin-layer chromatographic (HPTLC) method for separation and quantitative analysis of losartan potassium, atenolol, and hydrochlorothiazide in bulk and in pharmaceutical formulations has been established and validated. After extraction with methanol, sample and standard solutions were applied to prewashed silica gel plates and developed with toluene–methanol–triethylam...