PURPOSE The purpose of this study was to evaluate the chemical stability of Lincocin(®) (lincomycin hydrochloride) in commonly used intravenous fluids at room temperature (25°C), at accelerated-degradation temperatures and in selected buffer solutions. MATERIALS AND METHODS The stability of Lincocin(®) injection (containing lincomycin 600 mg/2 mL as the hydrochloride) stored at 25°C±0.1°C in ...

Although many attempts have been made by different investigators to isolate the carbohydrate group from various glycoproteins, only two amino sugars have so far been isolated: chitosamine (glucosamine) and chondrosamine. Chitosamine (1) was first isolated from lobster shells and later from other substances. In some cases the hydrochloride of chitosamine was obtained in crystalline form while in...

a, ar-Di(glycylamino)propionic acid hydrochloride, (NH&H2CONH)2C(CH,)COOH.HCl, is enzymatically hydrolyzed in aqueous extracts of rat kidney to yield, as a maximum, 1 mole of ammonia and 1 mole of pyruvic acid per mole of substrate (1). a-(dl-Chloropropionylamino)-a-(nI,-alanylamino)propionic acid and a:, ac-di(nL-alanylamino)propionic acid hydrochloride are also hydrolyzed by rat kidney, the f...

A new peptide antibiotic, brevistin, was isolated from the culture broth of Bacillus brevis 342-14. Brevistin is an acylpeptide with an approximate empirical formula of C63H91N15O18 containing aspartic acid, threonine, glycine, valine, isoleucine, phenylalanine, tryptophan and 2,4-diaminobutyric acid. The antibiotic is soluble in acid and alkaline water. Its hydrochloride is soluble in methanol...

A series of six L-amino acid hydrochloride salts has been studied by 35/37Cl solid-state NMR spectroscopy (at 11.75 and 21.1 T) and complementary quantum chemical calculations. Analyses of NMR spectra acquired under static and magic-angle-spinning conditions for the six hydrochloride salts, those of aspartic acid, alanine, cysteine, histidine, methionine and threonine, allowed the extraction of...

The main objective of the presented study was the development of a simple analytical tool for exploring the influence of naturally occurring compounds on the aggregation of amyloid-β peptide (Aβ(40)) in order to find potential anti-neurodegenerative drugs. The gold discs used for surface plasmon resonance (SPR) measurements were modified with thioaliphatic acid. The surface functionalized with ...

The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps. It is less costly and relatively easy to prepare this kind of fluorescent amino acid with the new synthetic method. Furthermore, it can be applied to synthesi...