1- (Phthalazin-l'-yl-amino)-3-chloro-4-aryl-4H-(4o-rm ethyl)-2-azetidinones (3) were prepared by cycloaddition of-methyl substituted benzal hydrazinophthalazine (2) with chloro acetylchloride. The hydrazone (2) was synthesised by the condensation of 1- hydrazinophthalazine (1) with substituted aromatic aldehydes, ketones 7 acetophenones. 1- Hydrazinophthalazine was prepared from the phthal...

A palladium-catalyzed, enantioselective, aryl-aryl cross-coupling reaction using 1-naphthyldimethylsilanolates and chiral bis-hydrazone ligands has been developed. A family of glyoxal bis-hydrazone ligands containing various 2,5-diarylpyrrolidine groups was prepared to evaluate the influence of ligand structure on the rate and enantioselectivity of the cross-coupling. New synthetic routes to th...

A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical ...

The 2-pyridinecarbaldehyde isonicotinoyl hydrazone (HPCIH) family of ligands are typically tridentate N,N,O chelators that exhibit very high in vitro activity in mobilizing intracellular Fe and are promising candidates for the treatment of Fe overload diseases. Complexation of ferrous perchlorate with HPCIH in MeCN solution gives the expected six-coordinate complex Fe(II)(PCIH)(2). However, com...

The reaction of 6-formyl-7-hydroxy-5-methoxy-2-methylbenzopyran-4-one with dimethyl acetylenedicarboxylate and benzil gave the respective 4H,6H-pyrano[3,2-g]chromene and imidazolylbenzopyran derivatives. Treatment of the imidazolylbenzopyran with hydrazine hydrate or hydroxylammonium chloride yielded imidazolylpyrazolylor imidazolylisoxazolylbenzenes, while the alkaline hydrolysis of imidazolyl...

A catalytic method has been developed for the determination of microgram amounts of mercury (II) based on its catalytic effect on the rate of a ligand substitution reaction. The reaction studied involved the substitution of cyanide in hexacyanoferrate (II) by resacetophenone benzoic acid hydrazone (2’, 4’dihydroxy propiophenone benzoic acid hydrazone) and the reaction was monitored spectrophoto...

Five new organotin(IV) complexes of ortho-vanillin2-hydrazinopyridine hydrazone with formula [RnSnCl4–n(VHP)] [R = Me2, n = 2 (2); R = Ph2, n = 2 (3); R= nBu2, n = 2 (4); R = nBu, n = 2 (5) and R = 1, n = 0 (6)] have been synthesized by direct reaction of orthovanillin-2-hydrazinopyridine hydrazone [(VHP), (1)], base and organotin(IV) chloride(s) in absolute methanol. The hydrazone ligand [(VHP...

Abstract The binding of low molecular weight compounds with the transport proteins blood is an essential step their delivery into living cells and thus accurate investigation interactions occurring in solution at physiological conditions crucial for development efficient biologically active molecules. In this work, we report on complex species, stability constants thermodynamic parameters react...

A zeolitic platinum-encapsulated microcapsule was successfully employed in the one-pot tandem synthesis of hydrazone directly from cyclohexanol with high conversion, selectivity and reusability due to the promising protection of the zeolitic shell around the catalyst.