Novel propargyl-ended heterobifunctional poly(ethylene glycol) (PEG) derivatives with hydroxyl, carboxyl, mercapto or hydrazide end groups were synthesized with simplicity yet high efficiency. PEG (Mw = 3500 Da) with an α-hydroxyl group and an ω-carboxyl was used as the starting polymer. The carboxyl group of the bifunctional PEG was modified into a propargyl, then carboxyl, mercapto or hydrazi...

Glycine, a photorespiratory intermediate, enhanced the in vivo reduction of nitrate in barley (Hordeum vulgare L.) leaf slices, when included in the assay medium. Isonicotinyl hydrazide, an inhibitor of glycine oxidation, partially reduced NO(2) (-) production. The enhancement caused by glycine treatment was reversed by isonicotinyl hydrazide when both were present together in the medium. Simil...

A number of 1,3,4-oxadiazole, 3-9, and 1,2,4-triazole derivatives, 13-15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a-c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalky...

The title compound, C21H17N3O5·C3H7NO, exists in an E conformation with respect to the azomethine double bond of the hydrazide mol-ecule. This mol-ecule contains an intra-molecular O-H⋯N hydrogen bond, while an inter-molecular N-H⋯O hydrogen bond links the hydrazide to the formamide mol-ecule of solvation. Nonclassical C-H⋯O inter-molecular hydrogen bonds build up a supra-molecular architecture...

IN THE TITLE COMPOUND (ALTERNATIVE NAME: pyridine-3-carbo-hydrazide, C(6)H(7)N(3)O), the asymmetric unit contains a single mol-ecule. In contrast with nicotinic acid and nicotinamide, the C=O bond is found to be oriented cis with respect to the C(ipso) C N fragment in the pyridine ring. The pyridine ring and the hydrazide group make a dihedral angle of 34.0 (2)°. In the crystal structure, mol-e...

In the title moleclue, C(13)H(10)N(4)O(3), the methyl-idene-hydrazide [-C(=O)-N-N=C-] fragment is essentially planar, with a maximum deviation of 0.0228 (7) Å. The mean planes of the benzene and pyridine rings make dihedral angles of 25.44 (6) and 5.47 (7)°, respectively, with the mean plane of the methyl-idene-hydrazide fragment. In the crystal structure, inter-molecular N-H⋯N hydrogen bonds l...

The conformation about each of the imine and ethene bonds in the title hydrazide hydrate, C(16)H(13)ClN(2)O·H(2)O, is E. The hydrazide mol-ecule is approximately planar (r.m.s. deviation of the 20 non-H atoms = 0.172 Å). The most significant twist occurs about the ethene bond [C-C=C-C = 164.1 (5)°] and the dihedral angle formed between the benzene rings is 5.3 (2)°]. In the crystal, the presenc...

In the title compound, C(16)H(17)N(3)O(2)·0.5H(2)O, the two hydrazide mol-ecules are approximately planar: the dihedral angles between the two substituted benzene rings are 7.7 (2) and 4.2 (2)°. Both hydrazone mol-ecules exist in a trans geometry with respect to their methyl-idene units. In the crystal, the water mol-ecule lies between the two organic mol-ecules and makes bifurcated O-H⋯(N,O) h...