BACKGROUND AND AIMS Hyperforin (HY) is used to treat depression and skin irritation and has been shown a number of pharmacological activities. The literature does no cite data on changes that may occur in the body after HY intake (ethylene diammonium salt - EDS) in long-term administration. From this point of view, the present work is a key to determining the pharmacotoxicological profile of th...

This investigation examined the distinct and interactive effects of initial hydration state, exercise-induced dehydration, and water rehydration in a hot environment. On four occasions, 10 men performed a 90-min heat stress test (treadmill walking at 5.6 km/h, 5% grade, 33 degrees C, 56% relative humidity). These heat stress tests differed in pretest hydration [2 euhydrated (EU) and 2 hypohydra...

The title compound, C25H24N4O2, adopts a cisoid configuration and has twofold orientational disorder of the 2-hy-droxy-ethyl group. The mol-ecule is twisted from planarity so that the dihedral angle between the terminating indol-2-yl-idene and the furan-2-yl-idene moiety mean planes is 12.75 (7)°. Conformational disorder occurs at the indol-2-yl-idene N atom, which results in two orientations f...

In the reaction of 8-hy-droxy-quinoline, 2-methyl-8-hy-droxy-quinoline and stannic chloride, the 2-methyl-8-hy-droxy-quinoline is protonated, yielding the disolvated title salt, (C(10)H(10)NO)[SnCl(4)(C(9)H(6)NO)]·2CH(3)OH. The Sn(IV) atom in the anion is N,O-chelated by the hy-droxy-quinolinate in a cis-SnNOCl(4) octa-hedral geometry. In the crystal, the cation, anion and solvent mol-ecules ar...

The Chinese Ocean Color and Temperature Scanner (COCTS) on board HY-1 series satellites has two thermal infrared channels with the spectrum range of 10.30-11.40 μm 11.40-12.50 for sea surface temperature (SST) observations. To reprocess Haiyang-1B (HY-1B) COCTS SST, Bayesian cloud detection optimal estimation (OE) SST retrieval were applied to data in this study. algorithm that been deve...

Inference: We approximately solve the inference problem by iterating the following two steps: 1. Holding Gy fixed, optimize hy (solved by Loopy BP): hy = argmax h’ wΨ(x,h’, y;Gy) 2. Holding hy fixed, optimize Gy (solved by integer linear program (ILP)): Gy = argmax G ′ wΨ(x,hy, y;G ) We define a variable z, zjk = 1 indicates that the edge (j, k) is included in the graph, and 0 otherwise. we enf...

Ovarian cancer is the fourth most frequent cause of cancer-related death in women in the United States. The currently recommended treatment is a combination of surgery followed by chemotherapy. However, ovarian cancer is characterized by the development of peritoneal micrometastases. These latter, hardly detectable by conventional method, are therefore suboptimally treated by standard surgery. ...

Hypericin-mediated photodynamic therapy (HY-PDT) has become a potential treatment for tumors and nonmalignant disorders. Some studies reported that HY-PDT could lead to apoptosis in some carcinoma cells. However, the molecular mechanism of HY-PDT remains unknown. In this study, we evaluated the molecular mechanisms of hypericin associated with light-emitting diode irradiation on the poorly diff...

We investigated the contribution of sarcoplasmic reticulum (SR) and Na+/Ca2+ exchanger in the tension-dependent change in the decay of the Ca2+ transients (CaT) in euthyroid (Eu) and hyperthyroid (Hy) myocardium. Hy was induced by thyroxine treatment to enhance the rate of SR Ca2+ uptake. With the use of the aequorin method, CaT and tension in twitch contraction were simultaneously measured und...

A stable, hydrogen-defect structure of post-perovskite (hy-ppv, Mg1 xSiH2xO3) has been determined by first-principles calculations of the vibrational and elastic properties up to 150 GPa. Among three potential hy-ppv structures analyzed, one was found to be stable at pressures relevant to the lower-mantle D 00 region. Hydrogen has a pronounced effect on the elastic properties of post-perovskite...