Advances in biomimetic three-dimensional (3D) melanoma models have brought new prospects of drug screening and disease modeling, since their physiological relevancy for recapitulating vivo tumor architectures is more accurate than traditional two-dimensional (2D) cell culture. Gelatin methacryloyl (GelMA) widely used as a tissue-engineered scaffold hydrogel 3D In the present study, an vitro mal...

background: chemical control method using different acaricides as spray, dipping solution or pour-on is routinely used for controlling ticks. biological control agents are favorable due to their safety for animals and environment. entomopathogenic fungi such as beauveria bassiana are well known for controlling ticks. in this study, two iranian indigenous strains of b. bassiana ( b. bassiana 519...

The goal of this report is i) to model the occurrence and hunting yield (HY) density wild ungulates not only for widely distributed species in Europe, but also those ones which have a constrained distribution ii) compare output with observed HY. Random Forest function was used modelling species. We data available from past 30 years, HY (period 2015-2020) records collected by ENETWILD. Like prev...

The aim of this study was to evaluate the effects of sodium hyaluronate (HY), single-walled carbon nanotubes (SWCNTs) and HY-functionalized SWCNTs (HY-SWCNTs) on the behavior of primary osteoblasts, as well as to investigate the deposition of inorganic crystals on titanium surfaces coated with these biocomposites. Primary osteoblasts were obtained from the calvarial bones of male newborn Wistar...

BACKGROUND The efficacy of rotigotine has been demonstrated in studies of patients with early (i.e. not receiving levodopa) and advanced (i.e. not adequately controlled on levodopa; average 2.5 h/day in 'off' state) Parkinson's disease (PD). OBJECTIVE To further investigate the efficacy of rotigotine transdermal patch across different stages of PD symptom severity and functional disability, a...

The poor prognosis of patients suffering from malignant glioma requires further efforts. Photodynamic therapy (PDT) might be a therapeutic option to increase surgical radicality. Hypericin (HY) exhibit high phototoxicity to malignant cells and accumulates to a higher extent in glioblastoma cells as compared to neurons. Therefore, the impact of various experimental parameters on cytotoxicity, in...

Epilobium and Chamaenerion included 165 8 species over the world, respectively. The members of genera are distributed particularly in moist habitats from subpolar to tropical regions.This paper aims provide improvements phylogeny using Internal Transcribed Spacer (ITS) nuclear DNA matK gene sequence data evaluation with maximum parsimony, likelihood, Bayesian inference criterations. A total 188...

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental pollutant, has been shown to cause thymic atrophy and apoptosis. However, whether TCDD alters the process of T-cell selection in the thymus is not clear. To this end, we investigated the effects of TCDD in the context of the HY-T-cell receptor (TCR) transgenic (Tg) mouse model. We noted that negatively selecting male HY-TC...

In this work, the impact of chemical additions, especially nano-particles (NPs), was quantitatively analyzed using our constructed artificial neural networks (ANNs)-response surface methodology (RSM) algorithm. Fe-based and Ni-based NPs ions, including Mg2+, Cu2+, Na+, NH4+, K+, behave differently towards response hydrogen yield (HY) evolution rate (HER). Manipulating size concentration found t...

Naturally derived regulatory T cells (Tregs) may prevent graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) activity. However, clinical application of naturally derived regulatory T cells has been severely hampered by their scarce availability and nonselectivity. To overcome these limitations, we took alternative approaches to generate Ag-specific induced Tregs (iTreg...