OBJECTIVE In vitro chemotherapy response assays are not widely accepted in making decisions regarding cytotoxic drugs. To evaluate the usefulness of chemotherapy response assays in breast cancer, we compared the chemotherapy response assay results according to subtypes. Human epidermal growth factor receptor-2 and Ki67 associated with chemosensitivity were also analyzed. METHODS Four hundred ...

Tumor-related vessel length (TVE) was quantified as the number of pixels skeletonized tumor vessels on ultrafast dynamic contrast-enhanced MRI (UF-DCE MRI). The association between TVE and breast cancer subtypes investigated. Invasive presenting with human epidermal growth factor receptor 2 (HER2) associated increased tumor-related length.

BACKGROUND To elucidate the clinicopathologic features and their implications on the immunohistochemistry in cases of molecular apocrine breast cancer (MABC). METHODS Immunohistochemical (IHC) staining for estrogen receptor (ER), human epidermal growth factor receptor 2 (HER-2), cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), androgen receptor (AR), gamma-glutamyltrasferase 1 (...

Introduction. One of the widely used specific anti-HER 2 (human epidermal growth factor receptor 2) MAb drugs is trastuzumab. Trastuzumab highly effective for malignant HER hyperexpression reduction, which results in oncogenicity decrease. As any other biotherapeutics trastuzumab can cause immunological adverse reactions, e.g. immunogenicity or anti-drug antibodies (ADAs) production. Aim. The a...

Background: Triple Negative Breast Carcinomas (TNBC) are breast carcinomas which negative for Estrogen receptor (ER) Progesterone (PR) and no overexpression of Human Epidermal Growth Factor receptor-2 (HER-2). The five-year survival rate in general is good but the same bad TNBC. TNBC has got worse prognosis compared to hormone positive carcinomas. Aim: aim present study compare invasive lobular...

The aim of this study was to investigate the correlation between apparent diffusion coefficients (ADCs), the relative apparent diffusion coefficient (rADC), and the pathological prognostic factor human epidermal growth factor receptor 2 (HER-2) in patients with breast cancer. A total of 64 women with breast cancer underwent breast diffusion-weighted imaging. HER-2 expression was detected in his...

The prognosis of patients with human epidermal growth factor receptor-2 (HER2)-overexpressed metastatic breast cancer (MBC) has improved drastically following the development anti-HER2 therapies. We question what factors are involved in outcome by treatment. One hundred and two MBC who received chemotherapy were classified into groups according to subtype: luminal/HER2-negative (n = 50), HER2 2...