background: diazinon (dzn) is an organophosphate insecticide which is used worldwide in agriculture. the exposure to this chemical might lead to damages to the living systems. objective: the present study was done to investigate the effects of diazinon on the structure of testis and levels of sex hormones in adult male mice. materials and methods: for this experiment, the mature male mice divid...

helicobacter pylori (h. pylori) is a gram-negative bacterium that colonizes the human stomach and affects more than half of the global human population. this microorganism shows variations in its geographical distribution and causes chronic gastritis, peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. the development of these clinical entities depends on the ba...

background: mesenchymal stem cells (mscs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. however, the low survival rate of these cells restricts their therapeutic applications. it is hypothesized that autophagy might play an important role in cellular homeostasis and survival. this study aims to investigate the regenerative potentia...

background: retinoic acid as one of the most important regulators for cell differentiation was examined in this study for differentiation of human umbilical mesenchymal cells (hucm). methods: after isolation, hucm were evaluated for mesenchymal stem cell properties by flow cytometry and alkaline phosphatase assay. also, doubling time of the cells and their differentiation potential into adipoge...

introduction: endothelial progenitor colony forming unit-endothelial cells (cfu-ec) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. further studies revealed that they are monocytes regulating vasculogenesis. the main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. this study was unde...

background: wound healing of burned skin remains a major goal in public health. previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds. methods: in this study, mesenchymal stem cells were derived from rat adipose tissues and characterized by flowcytometry. staining methods were used to evaluate their differentiatio...

there are two main methods for preparing the puramatrix (pm) as a three-dimensional (3-d) scaffold for supporting the cells including surface plating and encapsulation. in the surface-plating procedure, the scaffold is created by adding an ionic agent such as medium to pm. after adjusting the ph by changing the medium, cells are seeded on top of the scaffold. in the encapsulation method, pm and...

perivascular epithelioid cell tumor (pecoma) is composed of hmb45+ epithelioid cells with clear to granular cytoplasm and perivascular distribution. we describe a uterine pecoma in a 33 years old woman where tumor cells were positive for hmb45 but negative for epithelial markers and negative or positive for smooth muscles markers.

objective(s) the use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (msc) bone differentiation in culture. in this regard, there is no study considering the effects of matrigel on mesenchymal stem cell (msc) in vitro bone differentiation. this was the subject of the present study. materials and methods huma...