In this study a hierarchical hub location problem with two layers is considered. The first layer includes small hubs and the second one includes a star-shaped network central hub. The considered case is a cargo delivery network where there is hierarchy between hubs. All the hubs and links are capacitated and there are three kinds of commodities for each of which there is a special kind of vehic...

IMPORTANCE The human brain forms a large-scale structural network of regions and interregional pathways. Recent studies have reported the existence of a selective set of highly central and interconnected hub regions that may play a crucial role in the brain's integrative processes, together forming a central backbone for global brain communication. Abnormal brain connectivity may have a key rol...

Hub location problems, with the hub-and-spoke network structure, involve locating hub facilities, allocating the non-hubs (spokes) to the hubs, and determining the path for each origin-destination pair. In a pure hub-and-spoke network, all hubs, which act as intermediate switching or transshipment points for internodal flows, are fully interconnected and none of the non-hubs are directly connec...

Stem cells can be controlled by their local microenvironment, known as the stem cell niche. The Drosophila testes contain a morphologically distinct niche called the hub, composed of a cluster of between 8 and 20 cells known as hub cells, which contact and regulate germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Both hub cells and CySCs originate from somatic gonadal precursor c...

Hubs are facilities to collect arrange and distribute commodities in telecommunication networks, cargo delivery systems, etc. In this paper, an uncapacitated phub center problem in case of single allocation and also multiple allocation will be introduced in which travel times or transportation costs are considered as fuzzy parameters. Then, by proposing new methods, the presented problem is con...

As Personalized PageRank has been widely leveraged for ranking on a graph, the efficient computation of Personalized PageRank Vector (PPV) becomes a prominent issue. In this paper, we propose FastPPV, an approximate PPV computation algorithm that is incremental and accuracy-aware. Our approach hinges on a novel paradigm of scheduled approximation: the computation is partitioned and scheduled fo...

Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC). Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with tumor node metastasis (TNM) staging of BC patients. Functional enrichment analysis was conducted to functionally annotate the hub genes. Protei...

    Hub covering location problem, Network design,   Single machine scheduling, Genetic algorithm,   Shuffled frog leaping algorithm   Hub location problems (HLP) are synthetic optimization problems that appears in telecommunication and transportation networks where nodes send and receive commodities (i.e., data transmissions, passengers transportation, express packages, postal deliveries, etc....

The hub location problem is employed for many real applications, including delivery, airline and telecommunication systems and so on. This work investigates on hierarchical hub network in which a three-level network is developed. The central hubs are considered at the first level, at the second level, hubs are assumed which are allocated to central hubs and the remaining nodes are at the third ...

This paper uses the energy hub concept to meet the water, heat and electricity demand of a power plant in the Qeshm island in south of Iran. Given the power plant’s high potential for waste heat recovery and some scenarios were considered using the hub energy concept based on energy, exergy, environmental and economic analyzes in terms of meeting the demands of the hub and purchasing/selling en...