BACKGROUND Perillyl alcohol (POH) elicited anticarcinogenic effects in a number of cancer models and pharmacokinetic studies in humans revealed that PA is the major circulating metabolite following POH administration. MATERIALS AND METHODS Effects of PA or POH alone, or in combination with radiation, on human head and neck squamous cell carcinoma cell lines (HNSCC), were investigated using cy...

OBJECTIVE Mineral Trioxide Aggregate (MTA) is composed of Portland Cement (PC) and bismuth oxide (BO). Replacing BO for niobium oxide (NbO) microparticles (Nbµ) or nanoparticles (Nbη) may improve radiopacity and bioactivity. The aim of this study was to evaluate the radiopacity and cytotoxicity of the materials: (1) PC; (2) White MTA; (3) PC+30% Nbµ; (4) PC+30% Nbη. MATERIAL AND METHODS For t...

The two divergently transcribed H2A-H2B gene pairs in yeast are differentially regulated as a function of the copy number of histone genes. Transcription of an HTA2-lacZ reporter gene is independent of histone gene copy number. Transcription of an HTA1-lacZ gene can be repressed or derepressed, depending on the number of HTA plus HTB genes in cells. Regulation by histone gene dosage is dependen...

We exploit a policy change in the UK Help-to-Buy (HTB) equity loan scheme order to identify causal link between mortgage affordability and entrepreneurship activity at local level. contribute literature on relationship housing finance by demonstrating impact of government loans through release trapped liquidity. When less is required buy house, households could use ‘additional’ liquidity start ...

In this paper we present an intrusion detection module capable of detecting malicious network traffic in a SCADA (Supervisory Control and Data Acquisition) system, based on the combination of One-Class Support Vector Machine (OCSVM) with RBF kernel and recursive k-means clustering. Important parameters of OCSVM, such as Gaussian width σ and parameter ν affect the performance of the classifier. ...