نتایج جستجو برای: hsv1

تعداد نتایج: 375  

2014
Jianhua Gong Zhongde Wang Irina Polejaeva Ravi Salgia Chien-Min Kao Chin-Tu Chen Guangchun Chen Liaohai Chen

Humane use of preclinical large animal cancer models plays a critical role in understanding cancer biology and developing therapeutic treatments. Among the large animal candidates, goats have great potentials as sustainable sources for large animal cancer model development. Goats are easier to handle and cheaper to raise. The genome of the goats has been sequenced recently. It has been known th...

2009
P. Balasubramanian K. Jayalakshmi N. Vidhya R. Prasad A. Khaleefathullah Sheriff G. Kathiravan K. Rajagopal Sripathi M. Sureban

Partially purified methanolic extract of Cissus quadrangularis (belonging to Vitaceae member, South Indian medicinal plant) have been explored for antiviral activity and their phytochemical characterisation. In vitro antiviral activity against HSV type1 and 2, and Vero cells at non-cytotoxic concentration were determined. HSV1 and HSV2 showed more sensitivity against the partially purified comp...

2009
Wei-Lun Sun Ching-Fang Yu Li-Wu Chiang Chung-Shan Yu Chi-Shiun Chiang Te-Wei Lee Jem-Mau Lo

Received 6/17/2008; revised 8/11/2008; accepted 9/1/2008. For correspondence and reprints contact: Jem-Mau Lo, Professor, Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University. 101 Section 2, Kuang-Fu Road, Hsinchu 300, Taiwan. Tel: (886)35727308, Fax: (886)3-5718649, E-mail: [email protected] Background: 5-Iodo-arabino-uridine (IaraU) is a less toxic ...

A Ataei-Pirkooh , A Khorsand , H Safari , HR Monavvari , S Yaghobee ,

Background and Aims: Several studies have shown that there is greater number of viruses in deep periodontal pockets than in normal gingival sulcus. We also know that virus may have an important role in induction of Il-1β secretion by different human cells. In this study we intended to determine the capacity of Herpes simplex virus type 1 to stimulate Il-1β secretion in human gingival ...

2014
Thillai V. Sekar Kira Foygel Ohad Ilovich Ramasamy Paulmurugan

Metastatic breast cancer is an obdurate cancer type that is not amenable to chemotherapy regimens currently used in clinic. There is a desperate need for alternative therapies to treat this resistant cancer type. Gene-Directed Enzyme Prodrug Therapy (GDEPT) is a superior gene therapy method when compared to chemotherapy and radiotherapy procedures, proven to be effective against many types of c...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Philipp Mayer-Kuckuk Debabrata Banerjee Sundeep Malhotra Mikhail Doubrovin Marian Iwamoto Tim Akhurst Julius Balatoni William Bornmann Ronald Finn Steven Larson Yuman Fong Juri Gelovani Tjuvajev Ronald Blasberg Joseph R Bertino

Human cells exposed to antifolates show a rapid increase in the levels of the enzyme dihydrofolate reductase (DHFR). We hypothesized that this adaptive response mechanism can be used to elevate cellular levels of proteins fused to DHFR. In this study, mouse cells transfected to express a green fluorescent protein-DHFR fusion protein and subsequently exposed to the antifolate trimetrexate (TMTX)...

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