نتایج جستجو برای: hscs
تعداد نتایج: 3001 فیلتر نتایج به سال:
Activation of hepatic stellate cells (HSCs) results in cirrhosis and portal hypertension due to intrahepatic resistance. Activated HSCs increase their contraction after receptor agonist stimulation; however, the signaling pathways for the regulation of contraction are not fully understood. The aim of this study was to elucidate the change in contractile mechanisms of HSCs after cirrhotic activa...
The Cover Feature shows the potential profile of an aqueous zinc-ion hybrid supercapacitor (Zn-HSCs) based on commercial activated carbon (AC) and Zn foil with non-toxic non-flammable electrolyte. Zn-HSCs present a promising route to bridge gap between supercapacitors batteries due unique configuration merits in terms efficient utilization capacitance AC electrode at cell level effective suppre...
Humans and larger mammals require more blood cells per lifetime than mice because of their larger size and longer life expectancy. To investigate this evolutionary adaptation, we calculated the total number of nucleated marrow cells (NMCs) per cat, observing the distribution of (59)Fe to marrow, then multiplied this value (1.9 +/- 0.9 x 10(10) [mean +/- SD]) times the frequency of feline hemato...
Whether hematopoietic stem cells (HSCs) change with aging has been controversial. Previously, we showed that the HSC compartment in young mice consists of distinct subsets, each with predetermined self-renewal and differentiation behavior. Three classes of HSCs can be distinguished based on their differentiation programs: lymphoid biased, balanced, and myeloid biased. We now show that aging cau...
Hematopoietic stem cells (HSCs) are responsible for sustaining hematopoietic homeostasis and regeneration after injury for the entire lifespan of an organism. Maintenance of genomic stability is crucial for the preservation of HSCs, which depends on their efficient repair of DNA damage, particularly DNA double strand breaks (DSBs). Because of the paucity of HSCs and lack of sensitive assays, di...
The process of hematopoiesis is associated with hematopoietic stem cells (HSCs) and the hematopoietic microenvironment. Osteoblasts, derived from mesenchymal stem cells (MSCs), are one of the most important components in the hematopoietic microenvironment. Osteoblasts secrete a variety of cytokines including interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF), the...
Whether hematopoietic stem cells (HSCs) change with aging has been controversial. Previously, we showed that the HSC compartment in young mice consists of distinct subsets, each with predetermined self-renewal and differentiation behavior. Three classes of HSCs can be distinguished based on their differentiation programs: lymphoid biased, balanced, and myeloid biased. We now show that aging cau...
Zeb1, a zinc finger E-box binding homeobox epithelial-mesenchymal transition (EMT) transcription factor, confers properties of “stemness,” such as self-renewal, in cancer. Yet little is known about the function Zeb1 adult stem cells. Here, we used hematopoietic system well-established paradigm cell biology to evaluate Zeb1-mediated regulation We employed conditional genetic approach using Mx1-C...
Retinoids are micronutrients that are stored as retinyl esters in the retina and hepatic stellate cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme responsible for hydrolysis and release of retinyl esters from HSCs is unknown and the relationship between retinoid metabolism and liver disease remains unclear. We hypothesize that the patatin-like phospholipa...
• Loss of Gadd45a enhances HSC reconstitution on hematopoietic stress. • Gadd45a regulates DNA damage responses in HSCs. Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia.However, the functionofGadd45a inhematopoietic stemcells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a) mice showed a normal hematologic phenotype under h...
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