Haptoglobin (Hp), a member of the acute-phase reactants, has long been known as a major hemoglobin-binding protein associated with hemoglobin catabolism. Recent studies indicate that another important biologic function of Hp is the modulation of the immune response. We found that Hp is expressed at high levels in specific cells, including alveolar macrophages and eosinophils in diseased or infl...

Heating application efficiency is a crucial point for saving energy and reducing greenhouse gas emissions. Today, EU legal framework conditions clearly define how heating systems should perform, how buildings should be designed in an energy efficient manner and how renewable energy sources should be used. Using heat pumps (HP) as an alternative “Renewable Energy System” could be one solution fo...

The objective of the study was to assess whether the timing of increased dietary protein throughout the day influences the feelings of fullness during energy balance (EB) and restriction (ER). Nine men (age 48 (SEM 6) years; BMI 32·7 (SEM 0·7) kg/m) randomly completed five controlled feeding trials, each consisting of 3 d of EB, followed by 3 d of ER of a 3138 kJ/d (750 kcal/d) reduction). The ...

Helicobacter pylori (HP) can cause many diseases and malignant conditions. In the stomach, HP causes mucosal injury and inflammation. We determined the association of the platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) with HP-positive and HP-negative gastritis severity. We retrospectively reviewed 234 patients who had undergone upper gastrointestinal endoscopy for the inv...

The ability of hesperidin (HP) to form complexes with five metals; cobalt, nickel, zinc, calcium and magnesium was investigated. The complexation was studied using U.V spectroscopic titration, in methanol as well as aqueous buffer solutions (physiological conditions). Potential complexes were studied by IR and NMR spectroscopy, melting point and their solubility were also evaluated. The interac...

It has been suggested that the normal serum protein, haptoglobin (Hp), serves a bacteriostatic role by binding free hemoglobin (Hm), thus making heme iron unavailable for bacterial growth. Previous studies showed that, unlike Escherichia coli, Vibrio vulnificus was able to overcome this Hp-blocking effect. We report here a study on the iron-withholding property of the three major human Hp pheno...

BACKGROUND A genetically defined molecular heterogeneity of haptoglobin, characterized by the major phenotypic forms Hp 1-1, Hp 2-1, and Hp 2-2, has been associated with distinct clinical manifestations. To enable the use of DNA samples for the study of this polymorphism, we established a haptoglobin genotyping method based on PCR. METHODS Taking advantage of the selectivity of PCR, we amplif...

AIM The aim of this study is to survey the effect of Helicobacter Pylori on metabolic syndrome parameters in diabetic patients. BACKGROUND Helicobacter pylori (HP) infection is the most common infection in developing countries. Some studies showed the association between HP infection and insulin resistance. Insulin resistance is a major mechanism in the development of metabolic syndrome (MetS...

Background Depression, schizophrenia and panic disorder are common mental disorders in the community and hospitalized patients. These mental disorders negatively affect life quality and even expectancy of life. Haptoglobin (Hp) phenotype (Hp 1-1, 1-2, or 2-2) is associated with risk for cardiovascular diseases, but its association with psychiatric disorders, a growing concern in the modern soci...