Pelletization process first came into existence way back during the 1950s, when the first product was introduced to the market. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sus...

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. Drug release from hot-melt extruded (HME) tablets containing either chitosan or xanthan gum was pH and buffer species dependent and the release ...

The holt-melt extrusion technique has proven to be an advantageous method for preparation of solid dosage forms. The aim of this work was to evaluate the release profiles of sustained release cylinders produced by hot-melt extrusion. The cylinders were composed of inner and outer part, both containing theophylline [1]. Cylinders were 0.5cm or 1cm long. The two parts were extruded separately, cu...

OBJECTIVE The aim of this study was to evaluate the applicability of POVACOAT™, a hydrophilic PVA copolymer, as a solid dispersion (SD) carrier for hot-melt extrusion (HME). METHODS Bifendate (DDB), a water-insoluble drug, was chosen as the model drug. DDB was hot-melt extruded by a co-rotating twin screw extruder with POVACOAT™. The SD formability of POVACOAT™ was investigated by varying the...

one of the most important applications of carbon nanotubes (cnts) is as reinforcement of metal matrix composites, because of their excellent mechanical properties. in this study, al-tio2-multi walled carbon nanotubes (mwcnts) nanocomposite is fabricated using isostatic pressing followed by hot extrusion. mechanical alloying is used to mix powders of aluminium, tio2 and mwcnts. tio2 with the amo...

The development of metal salts-based nanocomposites is highly desired for the Fenton or Fenton-like reaction-based chemodynamic therapy cancer. Manganese sulfate (MnSO4)-dispersed nanoparticles (NPs) were fabricated with a hot-melt extrusion (HME) system colorectal cancer in this study. MnSO4 was homogeneously distributed polyethylene glycol (PEG) 6000 (as hydrophilic polymer) aid surfactants (...