PURPOSE OF REVIEW An exploration of the evidence that a history of migration is a risk factor for schizophrenia and an evaluation of those studies that seek an explanation for this. RECENT FINDINGS A meta-analysis found an increased risk for schizophrenia among first-generation and second-generation migrants and found a particularly high risk for migrants from countries where the majority of ...

CONTEXT Elevated prenatal homocysteine level is a plausible risk factor for schizophrenia because of its partial antagonism of N-methyl-D-aspartate receptors under physiologic glycine concentrations and its association with abnormal placental function and pregnancy complications. OBJECTIVE We examined whether elevated maternal levels of homocysteine during the third trimester were associated ...

Two of the most frequently investigated regions in diffusion tensor imaging studies in chronic schizophrenia are the uncinate fasciculus (UF) and cingulum bundle (CB). The purpose of the present study was to determine whether UF and CB white matter integrity were altered at the early stage of illness and specific to schizophrenia. Fifteen schizophrenia subjects and 15 affective psychosis within...

introduction: hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. we investigated a possible relationship between variants (snps) in genes for cytochrome 2d6 (...

Abstract Background Schizophrenia (SCZ) is a severe mental disorder in which people interpret reality abnormally. Different studies indicated complex polygenic control over SCZ. In the present study, we investigated potential correlation between ten SNPs among MicroRNA (MIR) and their target genes; rs369770942, rs143525573, rs200982455, rs530404895, rs753764536, rs374732351, rs4680, rs165599, r...

Identifying endophenotypic markers is crucial to schizophrenia research for finding appropriate preventive strategies. Working memory (WM) deficit has been suggested as a marker for schizophrenia but its presence in adolescents at high risk is understudied. We piloted a test of spatial WM function in adolescents at clinical high risk (CHR) for schizophrenia and in age- and IQ-matched low-risk c...

BACKGROUND A growing body of evidence suggests that migration is a risk factor for the development of schizophrenia, although the putative mechanism remains obscure. AIMS To examine immigrant background and history of foreign residence as risk factors for schizophrenia. METHOD Using data from the Danish Civil Registration System, we established a population-based cohort of 2.14 million pers...

schizophrenia is a sophisticated mental disability which has affected nearly1.1% of people all over the world. according to recent researches, the key proteins triggered in the immune system are cytokines which might also be taking part in the pathogenesis of schizophrenia. the aim of this study was to evaluate the relationship between the -1082g/a and +874t/a polymorphisms of il-10 and ifn-γ g...

To the Editor: With great interest, we read the study by Olfson et al1 of schizophrenia-related outpatient treatment of Medicaidfinanced patients after hospitalization. Unfortunately, the authors give no further information on what kind of follow-up treatment (eg, various antipsychotics, psychoeducation) the outpatients received. With respect to the risk of relapse and mental health outcomes,1 ...