Specific phosphorylation of serineand arginine-rich pre-mRNA splicing factors (SR proteins) is one of the key determinants regulating splicing events. Several kinases involved in SR protein phosphorylation have been identified and characterized, among which human DNA topoisomerase I is known to have DNA-relaxing activity. In this study, we have investigated the mechanism of splicing inhibition ...

BACKGROUND Colorectal cancer (CRC) is one of the most frequently occurring cancers in Japan, and thus a wide range of methods have been deployed to study the molecular mechanisms of CRC. In this study, we performed a comprehensive analysis of CRC, incorporating copy number aberration (CRC) and gene expression data. For the last four years, we have been collecting data from CRC cases and organiz...

Objective: To study the prevalence of ocular morbidity (abnormal condition) and various factors affecting it among school attending adolescents. Methods: A cross-sectional study was conducted to study abnormal ocular conditions like refractive errors, vitamin A deficiency, conjunctivitis, trachoma, ocular trauma, blephritis, stye, color blindness and pterygium among school adolescents of 10-19 ...

The eukaryotic initiation factor 4E (eIF4E) plays a pivotal role in the control of protein synthesis. eIF4E binds to the mRNA 5' cap structure, m(7)GpppN (where N is any nucleotide) and promotes ribosome binding to the mRNA. It was previously shown that a fraction of eIF4E localizes to the nucleus (Lejbkowicz, F., C. Goyer, A. Darveau, S. Neron, R. Lemieux, and N. Sonenberg. 1992. Proc. Natl. A...

Declaration I declare that this thesis has not been submitted as an exercise for a degree at this or any other university and it is entirely my own work. I agree to deposit this thesis in the Univer-sity's open access institutional repository or allow the library to do so on my behalf, subject to Irish Copyright Legislation and Trinity College Library conditions of use and acknowledgement. Summ...

sty : macros/latex/contrib/abstract memoir.cls :macros/latex/contrib/memoir 208 Really blank pages betweenchapters If you’re using the standard classes, youneed to take special action; the memoirclass and the Koma-Script classes providetheir own support for this — see below.Book (by default) and report (withopenright class option) ensure thateach chapter star...

Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease. In order to lower this risk, statins are used in clinical practice in addition to biologics. Rituximab, an anti-CD20 antibody approved for the treatment of RA, induces B-cell apoptosis by crosslinking and redistributing CD20 to cholesterol-rich lipid rafts. Statins have been shown in vitro to induce con...

This article conta ined descriptions of five new taxa of Mexican Euphorbiaceae. Euphorbia (sub g. Agaloma) na yarensis is endemic to pine-oak woodland in the mount ains of central Nayarit. It appears related to E. so ob yi but differs by possessing linear to linear-ovate leaves. Croton varelae is also endemic to central Nayarit. A key was provided to distinguish this spec ies. a member of sect....

A 1.5-kb region immediately downstream of the styABCD operon involved in styrene degradation in Pseudomonas putida CA-3 has been cloned. Sequence analysis revealed a 1,296-bp open reading frame, designated styE, and BLAST P database comparisons of the deduced StyE amino acid sequence revealed 33 to 98% identity with several membrane-associated ATPase-dependent kinase proteins involved in the ac...

This study focused on student abil­ eluded student responses to various the statistical procedures also showed ity to analyze and interpret motion writing activities. Possible relation­ no significant relationship between graphs following laboratory instruction ships between individualleaming style students' learning style preferences using interactive digital video as well preferences and stud...