BACKGROUND Human homologs (FEM1A, FEM1B, FEM1C) of nematode sex determination genes are candidate genes for polycystic ovary syndrome (PCOS). We previously identified a FEM1A mutation (H500Y) in a woman with PCOS; FEM1B has been implicated in insulin secretion. METHODS Women with and without PCOS (287 cases, 187 controls) were genotyped for H500Y and six FEM1A single nucleotide polymorphisms ...

BACKGROUND homB encodes a Helicobacter pylori outer membrane protein. This gene was previously associated with peptic ulcer disease (PUD) and was shown to induce activation of interleukin-8 secretion in vitro, as well as contributing to bacterial adherence. Its 90%-similar gene, homA, was previously correlated with gastritis. The present study aimed to evaluate the gastric disease association w...

BACKGROUND Several epidemiologic studies showed the significant association of insulin resistance with asthma. OBJECTIVE The aim of this study was to evaluate the association of insulin resistance with airway hyperresponsiveness (AHR) in adult population. METHODS 1,058 subjects who visited to the Seoul National University Hospital Gangnam Center from October 2007 to January 2009 for a routi...

BACKGROUND Drugs with unspecific stimulating effects on beta-cell secretion increase the homeostasis model assessment (HOMA)-B score, indicating improved beta-cell "function." We investigated whether the beta-cell protection provided by adding pioglitazone (PIO) to glimepiride (GLIM) in comparison to up-titrating the GLIM dose alone is reflected by appropriate changes in several measures of bet...

Homeostasis model assessment of insulin resistance (HOMA-IR) is a simple and useful method for evaluating insulin sensitivity. But it is difficult to apply to type2 diabetes patients treated with insulin. We have devised a method for measuring HOMA-IR and investigated the validity of HOMA-IR for evaluating insulin sensitivity in patients with type 2 diabetes on insulin therapy. In the first arm...

This study investigated the role of vaspin in the occurrence and development of type 2 Diabetic Retinopathy (DR). A total of 90 patients clinically diagnosed with type 2 diabetes mellitus (T2DM) were divided into Non-DR (NDR), Non-Proliferation DR (NPDR), and Proliferation DR (PDR) groups, while healthy subjects were included in a control group. Serum Fasting Blood Glucose (FBG), Fasting Insuli...

Results: Hepatic enzymes were positively associated with obesity measures, fasting insulin, and HOMA-IR. GGT was additionally associated with serum lipids and white blood cell count. GGT, but not AST or ALT, was a significant determinant of HOMA-IR independently of age, sex, and WT, body mass index, or percent body fat. The model that accounted for the largest portion of the variance in HOMA-IR...

We aimed to investigate the clinical implication of plasma xanthine oxidase (XO) activity in patients with type 2 diabetes mellitus (DM). Materials and methods. 127 were examined for DM (72 female 55 male). Serum biochemical variables include aspartate aminotransferase (AST), alanine (ALT), fasting (FPG) postprandial (PPG) glucose, glycohemoglobin A1c (HbA1c), total cholesterol, triglyceride, h...

Diabetes mellitus caused by insulin resistance is prompted obesity. Neuropeptide Nesfatin-1 was identified in several organs, including the central nervous system and pancreatic islet cells. peptide appears to be involved hypothalamic circuits that energy homeostasis control food intake. Adiponectin a plasma collagen-like protein produced adipocytes have been linked development of (IR), diabete...