نتایج جستجو برای: holmium 166
تعداد نتایج: 11032 فیلتر نتایج به سال:
beta-emitting 166Ho (t1/2 = 26.78 hours, E(beta)max = 1.8 MeV) complexed with the phosphonic acid chelator, 1,4,7,10 tetraazacyclododecane-1,4,7,10-tetra(methylene phosphonic acid) (DOTMP) at a ligand-to-metal ratio of 1.5:1 binds to bone. This radioactive complex is a marrow-ablating radiopharmaceutical that appears useful for preparation of bone marrow (BM) transplant recipients without the m...
The aim of this study was to determine whether shorter-lived radionuclides can reduce red marrow (RM) toxicity for i.p. radioimmunotherapy (RIT). The potential radionuclides, which included Lu-177, I-131, Y-90, Re-186, Re-188, and Ho-166, were attached to antibody CC49. Each radiopharmaceutical was assumed to have identical in vivo pharmacokinetics. Blood and whole body retention data acquired ...
tional settling or meridional circulation). Cosmic-ray nucleosynthesis models and observations of interstellar clouds indicate that the primordial ratio, f(Li), in the protoplanetary matter could have been as high as 0.3±0.5, which in turn would allow either the possibility of some Li depletion in the star or the ingestion of planets with even smaller mass. In this scenario we have assumed that...
Interleukin 17 (IL-17) is a cytokine associated with inflammation, autoimmunity and defense against some bacteria. Here we show that IL-17 can promote autoimmune disease through a mechanism distinct from its proinflammatory effects. As compared with wild-type mice, autoimmune BXD2 mice express more IL-17 and show spontaneous development of germinal centers (GCs) before they increase production ...
not seek treatment. Untreated chlamydial infection can persist for a year or more, leading to sustained risks of transmission.6 In 1988, the New York State Department of Health’s Bureau of Sexually Transmitted Disease (STD) Control initiated a screening program to assess the prevalence of chlamydial infection among women attending public health clinics throughout the state. In this article, we ...
In the 1960s, the thesis that dietary cholesterol contributes to blood cholesterol and heart disease risk was a rational conclusion based on the available science at that time. Fifty years later the research evidence no longer supports this hypothesis yet changing the dietary recommendation to limit dietary cholesterol has been a slow and at times contentious process. The preponderance of the c...
ING1 gene, the founding member of the ING tumor suppressor family, was originally identified through subtractive hybridization between normal mammary epithelial cells and breast cancer cell lines, and subsequent in vivo selection of genetic suppressor element that displayed oncogenic features. The four additional members of the ING family (ING2-5) were recently identified and all the gene produ...
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