Abstract Background Piliostigma reticulatum is a plant traditionally used to treat malaria, smallpox, neuralgia, dysentery, diarrhea, and rheumatism in Northern Nigeria. There no scientific evidence support the antimalarial activity of this plant. This work aims investigate vivo antiplasmodial methanol leaf extract (MPR) mice, infected with NK65 chloroquine-sensitive Plasmodium berghei . The or...