BACKGROUND The prevalence of systemic hypertension (SHT) in Shetland Sheepdogs has not been reported. HYPOTHESIS/OBJECTIVES SHT is common in Shetland Sheepdogs and positively correlated with proteinuria. Measurements of forelimb and hindlimb systolic arterial pressure (SAP) are comparable. ANIMALS Seventy-two clinically healthy, client-owned Shetland Sheepdogs. METHODS Forelimb and hindli...

The reciprocal apparatus of the hindlimb means that similar lameness characteristics are shared by many causes of hindlimb lameness in both the proximal and distal parts of the limb. It is rarely possible by evaluation of gait alone to identify accurately the source of pain causing lameness, although a combination of clinical signs may lead the clinician to suspect a site of pain. It is only th...

Skeletal muscle perfusion during exercise is impaired in heart failure, but the underlying mechanisms are poorly understood. One possibility is that sympathetic vasoconstriction is enhanced in exercising muscle in heart failure as a result of impaired counterregulatory mechanisms that normally act to attenuate vasoconstrictor responses. In healthy animals, sympathetic vasoconstriction in contra...

[Purpose] The purpose of this study was to elucidate the cathepsin-D involvement in signaling pathways for the survival and apoptosis of myofibers in rats with hindlimb-unloading in a low-temperature environment. [Subjects and Methods] Wistar rats were divided into two groups: a control group and a group that underwent hindlimb unloading in a low-temperature environment to induce muscle apoptos...

Vasoactive effects of supplemental pentobarbital anesthesia in the canine hindlimb microcirculation were documented in two groups of animals previously anesthetized with 30 mg/kg pentobarbital: Group I with a 5 mg/kg intravenous (iv) bolus of pentobarbital (n = 8) and Group II with a 5 mg/kg 2-min iv infusion of pentobarbital (n = 7). In Group I, measurements at baseline (BL) and 5, 15, 20, and...

Delp, Michael D., Patrick N. Colleran, M. Keith Wilkerson, Matthew R. McCurdy, and Judy MullerDelp. Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity. Am J Physiol Heart Circ Physiol 278: H1866–H1873, 2000.— Hindlimb unloading of rats results in a diminished ability of skeletal muscle arterioles to constrict in vitro and elevate vascul...

To determine the somatic sensory modalities conveyed by hindlimb somatic afferent inputs, the discharge of neurons in the nucleus tractus solitarius was recorded in anesthetized rats after electrical stimulation of either the contralateral sciatic nerve or L(6) spinal nerve, which innervates the hindlimb. The discharge of seven of eight cells was increased (P < 0.05) by capsaicin injected into ...

The present study examined the role of the somatosensory cortex in the plasticity of thalamic sensory maps. Thalamic plasticity was induced by the disruption of hindlimb input by unilateral destruction of nucleus gracilis. Unilateral somatosensory cortex lesions were performed either on the same day as or a week after the removal of hindlimb input. Multiple electrode penetrations enabled us to ...