Genome-wide association studies are likely to be conducted in large scale in the near future. In such studies, searching over hundreds of thousands of markers for the few ones that are associated with disease brings out the multiple-hypothesis testing problem in its severe form. We explore, in a two-stage design, how the use of false discovery rate (FDR) can alleviate the burden of a prohibitiv...

The complementary programs UniFrag and GenomePrimer were developed to provide a reliable high-throughput method to select the most unique regions within genomic DNA sequence(s) and design primers therein, involving minimal user intervention and maximum flexibility.

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Droplet-based microfluidics is a colloidal and interfacial system that has rapidly progressed in the past decade because of the advantages of low fabrication costs, small sample volumes, reduced analysis durations, high-throughput analysis with exceptional sensitivity, enhanced operational flexibility, and facile automation. This technology has emerged as a new tool for many recently used appli...

Here, the search for superconducting hydrides is supercharged by a high-performance screening process, leveraging Gaspari-Gyorffy theory to avoid expensive phonon calculations. Combined with stability and metallicity screening, this allows investigation of hundreds thousands candidates from across periodic table, found via crystal structure prediction. From best candidates, full electron-phonon...

Functional characterization of genes and their protein products is essential to biological and clinical research. Yet, there is still no reliable way of assigning functional annotations to proteins in a high-throughput manner. In this chapter, the authors provide an introduction to the task of automated protein function prediction. They discuss about the motivation for automated protein functio...

This paper reports on TEXTALTM, a deployed application that uses a variety of AI techniques to automate the process of determining the 3D structure of proteins by x-ray crystallography. The TEXTALTM project was initiated in 1998, and the application is currently deployed in three ways: (1) a web-based interface called WebTex, operational since June 2002; (2) as the automated modelbuilding compo...