Eukaryotic gene expression can be viewed within a conceptual framework in which regulatory mechanisms are integrated at three hierarchical levels. The first is the sequence level, i.e. the linear organization of transcription units and regulatory sequences. Here, developmentally co-regulated genes seem to be organized in clusters in the genome, which constitute individual functional units. The ...

This article reviews recent work towards modelling protein folding pathways using a bioinformatics approach. Statistical models have been developed for sequence-structure correlations in proteins at five levels of structural complexity: (i) short motifs; (ii) extended motifs; (iii) nonlocal pairs of motifs; (iv) 3-dimensional arrangements of multiple motifs; and (v) global structural homology. ...

Using a hierarchical-systems analysis, this paper supports the orthodox view of the mind. We claim that the orthodox mind – bounded by brains or bodies – is organized into various system levels, each of which is emergent from the dynamics of level below it. We see the extended mind hypothesis as borrowing terms from a high-level system of the orthodox mind and applying it to interactions betwee...

This article extends Bayarri and Berger’s (1999) proposal for model evaluation using “partial posterior” p values to the evaluation of second-stage model assumptions in hierarchical models. Applications focus on normal-normal hierarchical models, although the final example involves an application to a beta-binomial model in which the distribution of the test statistic is assumed to be approxima...

This paper presents linear models built for the purpose of investigating tempo-dependent interaction between two components of Polish speech rhythm, namely Rhythmic Prominence Intervals (RPI) and syllables, within the framework of coupled oscillator model ([1], [2], [3]). The relative coupling strength parameter (r) calculated from regression coefficients shows increasing strength of the lower-...

We propose a hierarchical texture compression algorithm for real-time decompression on the GPU. Our algorithm is characterized by low computational complexity, random access and hierarchical structure which allow us to access first three levels of encoded mip-map pyramid. The hierarchical texture compression algorithm HiTCg is based on block-wise approach, where each block is subject to local f...

This paper presents two hierarchical routing protocols. Hierarchical state routing protocol and Fisheye state routing protocol. The former is a multilevel routing protocol that provides nodes’ clustering in multiple levels, while the latter uses the fisheye technique to reduce the routing overhead. They both employ a hierarchical control structure and try to provide better routing solutions.

Bayesian data analysis involves describing data by meaningful mathematical models, and allocating credibility to parameter values that are consistent with the data and with prior knowledge. The Bayesian approach is ideally suited for constructing hierarchical models, which are useful for data structures with multiple levels, such as data from individuals who are members of groups which in turn ...