BACKGROUND AND AIMS In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action of yet unidentified genetic and/or environmental modifying factors. In mice, transcription factor N...

Vivien Dubois1 and Ni olas Gama2 1 DGA-MI, Fran e vivien.dubois m4x.org 2 EPFL, Switzerland ni olas.gama ens.fr Abstra t. HFE is a publi key s heme introdu ed by Patarin in 1996. An HFE publi key is a large system of polynomials in many variables over a small nite eld. This system results from some se ret omposition, based on whi h the owner an solve it to any arbitrary ve tor. While the se uri...

INTRODUCTION Despite improvements in treatment strategies for head and neck squamous cell carcinoma (HNSCC), outcomes have not significantly improved; highlighting the importance of identifying novel therapeutic approaches to target this disease. To address this challenge, we proceeded to evaluate the role of iron in HNSCC. EXPERIMENTAL DESIGN Expression levels of iron-related genes were eval...

We consider the basic version of the asymmetric cryptosystem HFE from Eurocrypt 96. We propose a notion of non-trivial equations as a tentative to account for a large class of attacks on one-way functions. We found equations that give experimental evidence that basic HFE can be broken in expected polynomial time for any constant degree d. It has been independently proven by Shamir and Kipnis [C...

We investigate the security of a generalization of HFE (multivariate and odd-characteristic variants). First, we propose an improved version of the basic Kipnis-Shamir key recovery attack against HFE. Second, we generalize the Kipnis-Shamir attack to Multi-HFE. The attack reduces to solve a MinRank problem directly on the public key. This leads to an improvement of a factor corresponding to the...

The aim of the study was to identify the prevalence of HFE gene mutations in Czech patients with chronic liver diseases and the influence of the mutations on iron status. The presence of HFE gene mutations (C282Y, H63D, and S65C) analyzed by the PCR-RFLP method, presence of cirrhosis, and serum iron indices were compared among 454 patients with different chronic liver diseases (51 with chronic ...

Iron overload is associated with acquired and genetic conditions, the most common being hereditary hemochromatosis (HH) type-I, caused by HFE mutations. Here, we conducted a hospital-based case-control study of 41 patients from the São Miguel Island (Azores, Portugal), six belonging to a family with HH type-I pseudodominant inheritance, and 35 unrelated individuals fulfilling the biochemical cr...

Background and aims: The role of the HFE S65C mutation in the development of hepatic iron overload is unknown. The aim of the present study was: (A) to determine the HFE S65C frequency in a Northern European population; and (B) to evaluate whether the presence of the HFE S65C mutation would result in a significant hepatic iron overload. Patients and methods: Biochemical iron parameters and HFE ...

The gene for hemochromatosis (HFE) is expressed in a variety of cells, including those not thought to be affected by this disease. The impact of HFE on iron transport was examined in B-lymphoid cell lines developed from a patient with hemochromatosis with the HFE C282Y mutation (C282Y cells) and an individual with the wild-type HFE gene (WT cells). Whereas both cell lines expressed HFE protein,...

BACKGROUND Iron is a pro-oxidant that may promote carcinogenesis. Mutations in the hemochromatosis (HFE) gene are associated with increased total body iron stores in some individuals. We assessed the risk of colon cancer among individuals with and without HFE gene mutations. METHODS We performed a population-based, case-control study in North Carolina. Case patients with colon cancer and cont...