نتایج جستجو برای: heterocycles
تعداد نتایج: 2986 فیلتر نتایج به سال:
Photochemical reactions of imines, hydrazones, oximes and related compounds provides an efficient access to radical intermediates in the synthesis heterocycles.
The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.
The syntheses of the novel pyrrolo[2,3-d]pyrimidine-based heterocycles as tricyclic analogues of O6-methylguanine are described. Compound 5 is a weak inhibitor of human O6-alkylguanine DNA alkyltransferase.
5-Membered heterocycles are employed to give a conformer independent DDA array of hydrogen bonds, resulting in enhanced binding affinity to a complementary AAD array in comparison to a DDA array employing a 6-membered ring.
A unique octanuclear copper(II) cluster with a saddle-shaped structural topology has been prepared from a large, flexible polydentate ligand comprising a 4,4'-bipyridine linker bearing four pendant pyrazolate heterocycles.
Saturated five-membered nitrogen heterocycles, such as pyrrolidines, indolines, and isoxazolidines, appear as subunits in a broad array of biologically active and medicinally significant molecules [1]. As such, the synthesis of these compounds has been of longstanding interest. Many classical approaches to the construction of these heterocycles involve the use of C N bond-forming reactions such...
In the past years, Pd0-catalyzed C(sp3)−H activation provided efficient and step-economical methods to synthesize carbo- heterocycles via direct C(sp2)−C(sp3) bond formation. We report herein that a 1,4-Pd shift allows access N-heterocycles which are difficult build reaction. It is shown o-bromo-N-methylanilines undergo at N-methyl group, followed by intramolecular trapping C(sp2)−H or another ...
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