Stable Isotope Labeled Glutathione I. Mezine, C. B. Bode, B. Raughley, S. Bhoopathy, A. Owen, I. J. Hidalgo Absorption Systems Purpose Drug-induced liver toxicity is one of the most common adverse drug effects, and formation of reactive metabolites (RM) could be a contributing factor. Troglitazone (TGZ), the model compound used in this study, was withdrawn from the market due to a high incidenc...

Photo by 193001056 © Yee Xin Tan on Dreamstime.com ABSTRACT Suicide and overdose, associated with perinatal mental health conditions, are the leading causes of maternal mortality in United States. Experts field using mood anxiety disorders (PMAD) as an umbrella term that includes many conditions bring to light lack screening treatment for There is a growing need equip Obstetricians Gynecologist...

Drug discovery in Pharma R&D is an information driven process requiring many disparate bits of data from many different sources, both structured and unstructured. Text mining is the key methodology used to extract entities and relationships from unstructured text in the quest for the knowledge needed to bring a safe and effective drug to market and beyond. Much of the insight needed in early dr...

Industry and scientists have worked to develop a high-dose refuge management plan that can effectively delay European corn borer (ECB) resistance to new genetically modified pesticidal corn. For a high dose, the corn expresses enough pesticide to kill all but the most resistant corn borers. For refuge, producers plant a traditional corn variety that allows susceptible corn borers to thrive and ...

•^A new polynoid polychaete, Minusculisquama hughesi n. gen., n. sp., from Northumberland Strait and Nova Scotia is described. The species is remarkable for its elongate and flattened body with only 15 pairs of minute elytra confined to the anterior region. It shows features characteristic of some polynoids found living commensally in the tubes of other polychaetes. Some polynoids from Eastern ...

Leucine-rich repeat-containing 8 (LRRC8) proteins have been identified as putative receptors involved in lymphocyte development and adipocyte differentiation. They remain poorly characterized and no specific function has been assigned to them. There is no consensus on how this family of proteins might function, because homology searches suggest that members of the LRRC8 family act not as plasma...

I n a r ecent seminal paper , Gi bs on and Wexl er ([1], GW) t ake i mpor t ant s t eps t o formal i zi ng t he not i on of l anguage l ear ni ng i n a ( ni t e) s pace whos e gr ammar s ar e char act er i zed by a ni t e number of parameters. One of t he i r ai ms i s t o char act er i ze t he compl exi t y of l ear ni ng i n s uch s paces . For exampl e , t hey demons t r at e t hat even i n ...