Bleeding changes the haemodynamics, compromising organ perfusion. In this study, the effects of bleeding followed by replacement with hydroxyethyl starch 130/0.4 (HES) or lactated Ringer's (LR) on cerebral oxygenation and electroencephalogram-derived parameters were investigated. Twelve young pigs under propofol-remifentanil anaesthesia were bled 30 mL/kg and, after a 20-minute waiting period, ...

abstract posttraumatic intravasation of fat and debris can lead to a cascade of events. hydroxyethyl starches (hes) markedly suppress neutrophil influx by decreasing pulmonary capillary permeability and facilitating tissue oxygenation by improving microcirculation. it was hypothesized that in hypoxemic femur injury patients undergoing operative stabilization, hes administration will prevent the...

BACKGROUND The application of hydroxyethyl starch (HES) for volume resuscitation is controversially discussed and clinical studies have suggested adverse effects of HES substitution, leading to increased patient mortality. Although, the intestine is of high clinical relevance and plays a crucial role in sepsis and inflammation, information about the effects of HES on intestinal function and bar...

COMPARISON OF HYDROXYETHYLSTARCH 130/0.4 AND RINGER’S LACTATE ON FIBRINOGEN LEVEL IN CAESAREAN OPERATIONS: A RANDOMIZED CLINICAL TRIAL
 Background and Aim:
 Colloids are effective in volume resuscitation but they have been shown to negative impacts on fibrin formation. The aim of this study is evaluate the effect using low dose HES solutions fibrinogen level caserean operations.
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BACKGROUND Several studies have described hypercoagulability in neurosurgery with craniotomy for brain tumor resection. In this study, hydroxyethyl starch (HES) 130/0.42 was used for hemodynamic stabilization and initial blood loss replacement. HES can induce coagulopathy with thromboelastographic signs of decreased clot strength. The aim of this study was to prospectively describe perioperativ...

BACKGROUND The application of hydroxyethyl starch (HES) for volume resuscitation is controversially discussed and clinical studies have suggested adverse effects of HES substitution, leading to increased patient mortality. Although, the intestine is of high clinical relevance and plays a crucial role in sepsis and inflammation, information about the effects of HES on intestinal function and bar...

s published since July 2011. We identified 264 relevant publications where the primary analysis involved the use of HES APC data, and a further 130 papers where HES data had been linked to cohorts created in other datasets. The annual number of publications using HES APC data has increased from 2 in 1993 to 88 in 2015. Published studies using HES APC data have covered a diverse range of topics....

BACKGROUND Hydroxyethyl starch (HES) is applied to achieve volume expansion during surgery; however, nephrotoxicity may be induced in patients with sepsis. Simultaneously, neutrophil gelatinase-associated lipocalin (NGAL) and IL-18 have been illustrated as pivotal indicators to diagnose the acute kidney injury (AKI) early. This multi-center, randomized, double-blinded, placebo-controlled study ...

Hüter and colleagues recently published an experimental paper about possible pathomechanisms of hydroxyethyl-starch (HES)-induced adverse effects on renal function in an isolated perfusion model of 6 hours [1]. The authors should be congratulated for their attempt to shed light on the influence of different HES preparations on renal function, combining functional results and histological data. ...

INTRODUCTION Six percent hydroxyethyl starch (HES) 130/0.4 is considered an alternative to human albumin (HA) and crystalloids for volume replacement in children undergoing cardiac surgery. In this large propensity-matched analysis, we aimed to assess the efficacy and safety of replacing HA with HES for intraoperative volume therapy in children undergoing cardiac surgery with cardiopulmonary by...