introduction genetic evaluation and estimation of breeding value are one of the most fundamental elements of breeding programmes for genetic improvement. recently, genomic selection has become an efficient method to approach this aim. the accuracy of estimated genomic breeding value is the most important factor in genomic selection. different studies have been performed addressing the factors a...

Analysis of high-density SNP data in outbred populations to identify SNP that are associated with a quantitative trait requires efficient ways to handle large volumes of data and analyses. When using mixed animal models to account for polygenic effects and relationships, genetic parameters are not known with certainty, but must be chosen to ensure proper evaluation of SNP across chromosomes and...

Heritability of brain anatomical connectivity has been studied with diffusion-weighted imaging (DWI) mainly by modeling each voxel's diffusion pattern as a tensor (e.g., to compute fractional anisotropy), but this method cannot accurately represent the many crossing connections present in the brain. We hypothesized that different brain networks (i.e., their component fibers) might have differen...

Background: The investigation of heritability stands out as an important means to establish the weight of genetic and environmental factors in the development of social anxiety disorder. Objective: This study aims to make a critical review of methodological designs used in the investigation of the social anxiety disorder (SAD) heritability. Methods: We reviewed 31 research articles published un...

A sizable fraction of testicular germ cell tumour (TGCT) risk is expected to be explained by heritable factors. Recent genome-wide association studies (GWAS) have successfully identified a number of common SNPs associated with TGCT. It is however, unclear how much common variation there is left to be accounted for by other, yet to be identified, common SNPs and what contribution common genetic ...

OBJECTIVE To estimate the heritability of tinnitus. DESIGN Self-report questionnaire data collected from August 1, 1995, through June 30, 1997, from individuals in the Nord-Trøndelag Hearing Loss Study (an integrated part of the Nord-Trøndelag Health Study) were used. The study also included information on first-degree family relationships, and age-corrected polychoric correlations of relativ...