BACKGROUND Since hypercoagulability might result in recurrent miscarriage, anticoagulant agents could potentially increase the live-birth rate in subsequent pregnancies in women with either inherited thrombophilia or unexplained recurrent miscarriage. OBJECTIVES To evaluate the efficacy and safety of anticoagulant agents, such as aspirin and heparin, in women with a history of at least two mi...

Background: Recurrent miscarriage (RM) is defined as two or more consecutive pregnancy losses before 20 weeks of gestation as an important clinical problem, with an incidence of 1-3% among couples wishing to have children. There are several factors in the etiology of recurrent miscarriage. One of the main genetic causes which involve in the pathogenesis of RM is balanced chromosomal rearrangeme...

Hereditary thrombophilia is associated with an increased risk of fetal loss. Assuming that fetal loss is due to placental thrombosis, anticoagulant treatment might improve pregnancy outcome. In an observational family cohort study, we prospectively assessed the effects of anticoagulant drugs on fetal loss rates in women with hereditary deficiencies of antithrombin, protein C or protein S. The c...

Purpose: The aim of this study was vto demonstrate the impact anti-parietal cell antibody (APCA) positivity in women with poor obstetric history and skin disorders.
 Materials Methods: This retrospective cohort consisted 63 having disorders history. Patients were grouped into control (women only, n=50) groups APCA positivity, n=13). compared terms demographic findings, BOI, risk factors fo...

It is now possible to identify hereditary and acquired risk factors in a substantial percentage of patients presenting with a venous thrombotic event. The clinician is faced with an ever-growing number of laboratory tests that can be ordered in such patients, and there is considerable uncertainty as to how this information should be utilized in patient management. Some have argued that widespre...

Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is cons...

Protein S (PS) deficiency, an autosomal dominant hereditary thrombophilia, is more prevalent in East Asian populations than in Caucasians. PS-deficient patients have historically been administered a heparin product followed by warfarin for the treatment and secondary prevention of venous thromboembolism (VTE). However, warfarin can be ineffective or causes detrimental effects in rare cases. Whi...