In this issue of Blood, Safeukui et al have come to grips with an important issue in red blood cell (RBC) biology.1 Their study deals not only with the mechanism of RBC removal in diseases like hereditary spherocytosis (HS) and autoimmune hemolytic anemia, but also with RBC senescence.

295 Abstract: To investigate erythrocyte membrane protein abnormalities in Çukurova region we studied a family observed to be hereditary spherocytosis. Diagnosis was made basis of clinical features. By densitometric tracing of SDS-PAGE stained by Coomassie Brillant Blue, we found two spectrin deficiency, one ankyrin deficeiency, two spectrin-band 3 deficiency, one ankyrin-band 3 deficiency and ...