Diffuse glomerulonephritis was induced in unilaterally nephrectomized albino rabbits by giving them two massive intravenous injections of purified bovine serum gamma globulin. Morphologically, these renal lesions were similar to those of human acute and subacute glomenilonephritis. Globulin nephritis in rabbits also closely resembles experimental nephritis induced by injection of other foreign ...

Karsner (1908) described 'congenital nephritis' in an infant who died 45 minutes after a normal birth, and Lapage (1932) discussed acute haemorrhagic nephritis in an 11-day-old boy who died in a few days. Conrad (1938) gave a resume of three infants with neonatal nephritis for which no cause was found. One infant died on the seventh day of life, but the others recovered. Generalized oedema, hae...

Methods Twenty-four patients (16 female) with pSLE nephritis (44 serum samples, 22 in active nephritis) and 21 patients (18 female) with pSLE without nephritis (32 serum samples, 19 in active pSLE) were enrolled in the study. The disease control group included 17 patients with nephritis of other causality (Henoch-Schönlein purpura nephritis, IgA nephropathy, postinfectious glomerulonephritis, m...

Recently the number of diseases coming under the aetiology of allergic reactions has shown a rapid increase and so also the number of patients suffering from allergic affectionsOne of these diseases is acute nephritis. Knowledge acquired from clinical experience an experimental work tends to show that acut < nephritis or type I nephritis is due to allergy inflammatory changes in the glomerular ...

BACKGROUND Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe membranoproliferative lupus nephritis in (NZBxNZW)F1 mice. As this may represent a basic mechanism in the progression of lupus nephritis, several aspects o...

Lupus nephritis is one of the most serious manifestations and one of the strongest predictors of a poor outcome in systemic lupus erythematosus (SLE). Recent evidence implicated a potential role of interlukin-17 (IL-17) in the pathogenesis of lupus nephritis. However, the correlation between IL-17 expression level and the severity of lupus nephritis still remains incompletely understood. In thi...

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, characterized by an autoantibody response to various nuclear and cytoplasmic antigens. Renal disease in SLE occurs in 40-75% of patients, most often within five years of onset of disease, and is one of the strongest predictors of a poor outcome. A hallmark of glomerular involvement in lupus nephritis is the presence of auto...

OBJECTIVE To describe the renal lesions in Bull Terrier polycystic kidney disease (BTPKD), to confirm that the renal cysts in BTPKD arise from the nephron or collecting tubule, and to identify lesions consistent with concurrent BTPKD and Bull Terrier hereditary nephritis (BTHN). DESIGN Renal tissue from five Bull Terriers with BTPKD and eight control dogs was examined by light and transmissio...

BACKGROUND Geographical variation in lupus nephritis epidemiology may indicate important environmental factors contributions to the etiology of lupus nephritis. This paper first describes the epidemiology of biopsy-proven lupus nephritis in China by performing a systematic literature review and the possible social-environmental influential factors. METHODS The keywords "lupus nephritis", "ren...

Henoch-Schönlein purpura nephritis and IgA nephropathy are currently considered to be different clinical presentations of the same disease. There is need for a reliable proven, morphologic classification that can help clinicians more accurately formulate treatment strategies for patients with Henoch-Schönlein purpura nephritis. Considering that Henoch-Schönlein purpura nephritis and IgA nephrop...