نتایج جستجو برای: hepatic enzyme activities
تعداد نتایج: 679459 فیلتر نتایج به سال:
Compared with controls, patients with alcoholic fatty liver showed a significant increase of gamma-glutamyltransferase activity both in the liver and serum, whereas alkaline phosphatase activity was raised only in the liver but not in the serum. The activities of other enzymes such as aspartate aminotransferase, alanine aminotransferase and glutamate dehydrogenase remained virtually unchanged i...
Alkaline phosphatase (EC 3.1.3.1) isoenzymes in serum may be determined by multicomponent analysis of the enzyme activities in the presence of multiple inhibitors. To determine inhibition coefficients of the isoenzymes, we used multiple linear regression analysis to compare alkaline phosphatase activities in the presence of known inhibitors with electrophoretically determined isoenzyme activiti...
BACKGROUND Chronic arsenic exposure has been shown to cause liver damage. However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented. The aim of our study was to investigate the dose-response relationship between arsenic exposure and major serum enzyme marker activity associat...
Liver function tests, thyroxin and triiodothyronine levels, and hepatic 5’deiodinase and glutathione peroxidase enzyme activities were measured. Triiodothyronine levels in the carbon tetrachloride group and carbon tetrachloride + selenium group were significantly lower than in the control group (P<0.01, P<0.05, respectively). In the carbon tetrachloride + selenium group, the level of triiodothy...
Background and objectives: Diisononyl phthalate (DINP) is a class of phthalates are known to be metabolism disrupting chemicals (MDCs). Numerous MDCs, which humans exposed, have an effect on every aspect energy transduction. They affect the liver by impairing insulin secretion in pancreatic cells altering liver’s insulin-dependent glucose metabolism. Methods: For this study, eighteen male albin...
The cytochrome P450 enzyme superfamily (CYP), E.C. 1.14.-.-, are haem-containing monooxygenases with a vast range of both endogenous and exogenous substrates. These include sterols, fatty acids, eicosanoids, fat-soluble vitamins, hormones, pesticides carcinogens as well drugs. Listed below the human enzymes, their relationship rodent CYP activities is obscure in that species orthologue may not ...
The induction of a certain group of hepatic monooxygenase activities by polycyclic aromatic compounds is regulated by the same locus or gene cluster controlling the formation of cytochrome P1-450 (P-448) in mice. Certain inbred strains of mice are "responsive" (Ahb) to such induction, whereas others are "nonresponsive" (Ahd). A pair of closely related sublines that differ with respect to the Ah...
Transcriptomic studies are facilitating the search for the molecular bases of adaptation in natural populations, but the impact of these differences in mRNA content on animal physiology are often unknown. One way to determine if molecular changes have the potential to influence animal physiology and performance is to test for correlated changes at higher levels of biological organization, inclu...
Biological Responses of the Rat to Polychlorinated Biphenyls. BRUCKNER, J. V., KHANNA, K. L. and CORNISH, H. H. (1973). Toxicol. Appl. Pharmacol. 24, 434-448. A commercial polychlorinated biphenyl mixture (PCBs), Aroclor 1242, was administered to rats po by intubation in order to determine toxic manifestations of acute and subacute ingestion. In addition, the effect of PCBs on hepatic microsoma...
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