A chiral macrocyclic ytterbium cationic complex catalyses the nitro-aldol reaction between alpha-ketocarboxylates and nitromethane under ambient aqueous conditions, leading to the formation of for example, methyl-2-hydroxy-2-methyl-3-nitropropanoate in 96% yield and 59% enantiomeric purity. Monitoring of the paramagnetically shifted intermediate Yb species by (1)H NMR allows several different s...

1301. Outpatient Parenteral Antimicrobial Therapy (OPAT) in Intravenous Drug Users (IVDUs): Epidemiology and Outcomes Eleni Papalekas, BS; Niral Patel, MD; Alyssa Neph, BS; Daniela Moreno, BS; Marcus Zervos, MD; Katherine C. Reyes, MD; Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI; Internal Medicine, Henry Ford Hospital, Detroit, MI; Infectious Di...

OBJECTIVE Catherine de Medici, queen consort of King Henry II of France, was a powerful woman at a time when power for her sex was determined by fecundity. A decade long history of infertility might have placed her at risk for condemnation, but her husband's known urologic abnormalities played in her favor. This presentation will address the penile deformity of her husband, Henry II, and how th...

One-pot multistep stereoselective cascade reactions were implemented for the straightforward synthesis of various nitrocyclitols. Two kinases, an aldolase and a phosphatase were involved in this process together with a spontaneous intramolecular Henry reaction to provide a nitrocyclitol moiety. The C-C bond formation catalyzed by the aldolase and the nitroaldol reaction were key steps to build ...

The title compound, C(24)H(27)NO(9), is one of the epimers of the Henry reaction of 3-O-benzyl-6-O-benzoyl-2-O-isopropyl-idene-a-d-glucofuran-5-one with nitro-methane. The conformation of the five membered rings is as expected from the precursor compound and the mol-ecule is folded with a dihedral angle of 51.4 (2)° between the aromatic rings. One O-H⋯O hydrogen bond and some intra-molecular an...

A highly efficient catalyst system assembled from enantiomerically pure diaminocyclohexane and Ni(OAc)(2) is, for the first time, used to catalyze the cascade Michael-Henry reaction of various diones and substituted nitroalkenes. A series of polyfunctionalized bicyclo[3.2.1]octane derivatives containing four stereogenic centers are prepared with excellent enantioselectivities (up to >99% ee) an...

The effect of heterogeneity on seawater intrusion is analyzed. Heterogeneity in hydraulic properties such as hydraulic conductivity is well known to significantly affect groundwater flow and solute transport. Yet, few studies [Mc Kribbin and O`Sullivan, 1980; Schincariol and Schwartz, 1990; Schincariol et al., 1997 and 1998; Simmons et al., 2001] have focused on evaluating the impact of heterog...