Studies were carried out during the neonatal period in three infants with D1 trisomy syndrome to measure the proportion of fetal and adult hemoglobin being synthesized. These values were compared on the one hand to those previously reported from samples obtained from cord blood of normal newborn infants ranging from 25 to 43 wk gestation, and on the other hand to those values determined in crit...

Hb D is a clinically silent condition, but co-inheritance of Hb D with sickle cell or thalassemia produces clinically significant conditions like sickle cell anemia or thalassemia intermedia and chronic hemolytic anemia of moderate severity. Here we present a case of homozygous Hb D with alpha 3.7kb deletion and phenotypic effect on patients. Diagnosis of Hb D patient was performed by high perf...

background: considerable evidence suggests that oxidative stress affects diabetes mellitus (dm) and contributes to its complications. vitamin d has been shown to possess antioxidant properties. the aim of this study was to determine the association between serum levels of calcifediol (25-oh-d), an indicator of vitamin d status, and lipid profiles with oxidative stress in patients with type 2 di...

IFFERENCES IN THE HEMOGLOBINS of the adult and the newborn have been recognized since 1866 (36). Rapid advances in this field, however, began in 1949, when Pauling and Itano (25) discovered that the hemoglobin of sickle cell disease differs from adult hemoglobin. Since that time, 8 hemoglobins have been identified, hemoglobin C (18) in 1950, hemoglobin D (14) in 1951, hemoglobin E (7, 17) and h...

BACKGROUND Vitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and insulin resistance (HOMA-IR) in T2DM subjects. METHODS Present study was carried out in 912 subjects (429 T2DM cases and 483 non-diabetic controls) from Western India. The enrolled s...

Background The discovery of vitamin D is one of medicine's great achievements. Despite all the positive evidence emerging about the beneficial effect of vitamin D, we still find many are vitamin D deficient. The purposes of this study were to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and glycosylated hemoglobin (HbA1c) levels, to test the hypothesis that lower 25(OH)D ...

Severe adverse events have been observed following the infusion of Hemoglobin Based Oxygen Carriers (HBOCs) in patients subjected to elective orthopedic procedures, cardiopulmonary bypass surgery, and vascular surgical procedures. Along with all three of the hemoglobin based oxygen carriers, the patients received Ringer’s D,L-lactate as the resuscitation fluid, Ringer’s D,L lactate in the excip...

Background: According to the recent studies, vitamin D deficiency has been correlated with progress in type 2 Diabetes and Metabolic Syndrome. The aim of this study was to assess the effect of vitamin D supplementation on glucose and lipid profiles, blood pressure, and biomarkers of liver and kidney in type 2 diabetic patients.    Methods: In this Double blinded randomized clinical t...