OBJECTIVE Diabetes and hypertension often co-occur and share risk factors. Hypertension is known to predict diabetes. However, hyperglycemia also may be independently associated with future development of hypertension. We investigated glycated hemoglobin (HbA(1c)) as a predictor of incident hypertension. RESEARCH DESIGN AND METHODS We conducted a prospective analysis of 9,603 middle-aged part...

conclusions this investigation revealed that berberis fruit extract has beneficial metabolic effects in patients with type ii diabetes. barberry may improve glucose catabolism via glycolysis pathway, stimulate insulin secretion or improve insulin function and finally decrease glucose uptake. our results indicated that berberis fruit regulates glucose metabolism in patients with type 2 diabetes....

OBJECTIVE Long-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI gain or 2) long duration of overweight and obesity. RESEARCH DESIGN AND METHODS Participants in the 1958 British birth cohort with child to adu...

CONTEXT Regular exercise improves glucose control in diabetes, but the association of different exercise training interventions on glucose control is unclear. OBJECTIVE To conduct a systematic review and meta-analysis of randomized controlled clinical trials (RCTs) assessing associations of structured exercise training regimens (aerobic, resistance, or both) and physical activity advice with ...

BACKGROUND Nephropathy is one of the complications of type 2 diabetes mellitus that could lead to end-stage renal disease. Persistent microalbuminuria is the best predictor of high risk of developing diabetic nephropathy. The relation between HbA 1c and microalbuminuria with the duration of diabetes is not clear. OBJECTIVES To determine microalbuminuria levels in type 2 diabetics and to corre...

The routine measurement of hemoglobin A1c (Hb A1c) 1 has become an essential component of the standard of care for patients with diabetes and has been recommended by major clinical diabetes organizations. A small amount of evidence shows that having the Hb A1c result at the time of the doctor’s visit is beneficial (1 ). Recently, there has been discussion about whether the quality of point-ofca...

Preconception obesity is a strong predictor of glucose intolerance during pregnancy that has the potential to lead to adverse maternal and offspring effects. An increased prevalence of overweight offspring of obese mothers has been reported, despite normal values in an oral glucose tolerance test (OGTT) during pregnancy (1 ). Such findings might reflect effects of the intrauterine milieu, genet...

BACKGROUND Allowable total error (TE(a)) goals for hemoglobin (Hb) A(1c) require minimal assay imprecision and bias and implementation of a robust QC monitoring program. Here, we compare the combined influence on the risk of reporting unreliable results of TE(a) goals, a routine QC practice, and assay performance characteristics of 6 Hb A(1c) instruments across 4 academic medical centers. MET...

BACKGROUND Stability and transport challenges make hemoglobin (Hb) A(1c) measurement from EDTA whole blood (WB) inconvenient and costly for large-scale population studies. This study investigated Hb A(1c) measurement from WB blotted on filter paper (FP) in a Level I National Glycohemoglobin Standardization Program (NGSP)-accredited laboratory. METHODS Three Bio-Rad Variant™ II HPLC instrument...

There is no argument that improving mean levels of glycemic control as judged by assays for glycated hemoglobin (HbA(1c)) reduces the risks of microvascular complications and cardiovascular disease events in patients with type 1 and type 2 diabetes. However, observations in some trials have suggested that targeting HbA(1c) to suggested targets may not always result in improved outcomes for peop...