نتایج جستجو برای: heme degradation

تعداد نتایج: 168831  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
James R Abshire Christopher J Rowlands Suresh M Ganesan Peter T C So Jacquin C Niles

Heme is ubiquitous, yet relatively little is known about the maintenance of labile pools of this cofactor, which likely ensures its timely bioavailability for proper cellular function. Quantitative analysis of labile heme is of fundamental importance to understanding how nature preserves access to the diverse chemistry heme enables, while minimizing cellular damage caused by its redox activity....

Journal: :The Journal of biological chemistry 1998
K K Elbirt A J Whitmarsh R J Davis H L Bonkovsky

Heme oxygenase-1 is an inducible enzyme that catalyzes heme degradation and has been proposed to play a role in protecting cells against oxidative stress-related injury. We investigated the induction of heme oxygenase-1 by the tumor promoter arsenite in a chicken hepatoma cell line, LMH. We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproduci...

Journal: :Proceedings of the National Academy of Sciences 2006

2017
Aleksandra Bednarz Olga Pierzchała Mateusz Ogórek Aneta Jończy Robert Staroń Rafał R. Starzyński Paweł Lipiński Małgorzata Lenartowicz Andżelika Borkowska Narcyz Knap Jan Kaczor Jędrzej Antosiewicz

Neonatal jaundice (neonatal hyperbilirubinemia) is a physiological process caused by degradation of foetal erythrocytes. In humans, it starts in the second day of life and finishes at about day 10. During this short period in the organism of neonate large amounts of bilirubin – product of heme decay are generated as an effect of haemolysis of foetal erythrocytes. Because of impaired bilirubin c...

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