Advances in treatment of cancer patients and improved understanding of pathophysiological mechanisms behind malignant diseases contribute to increased survival and, consequently, increasing needs of intensive care support for this population.(1) It should be highlighted that ‘cancer’ is a name generically given to a widely heterogeneous group of diseases; in comparison to solid tumors, hematolo...

Early diagnosis of neonatal sepsis (NS) is difficult because the variable and non-specific clinical presentation. Also, many laboratory tests are negative at early stage diseases, so study aimed to detect role procalcitonin (PCT) in detection NS versus C-reactive protein (CRP) other hematological parameters.

Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence fr...

Hematopoietic stem cell transplantation (HSCT) is the first field where human stem cell therapy was successful. Flooding interest on human stem cell therapy to cure previously incurable diseases is largely indebted to HSCT success. Allogeneic HSCT has been an important modality to cure various diseases including hematologic malignancies, various non-malignant hematologic diseases, primary immun...

Zhong Yi Xue Ye Bing Xue (Theory of Chinese Medical Hematology), Sun Wei-zheng, ed., National Chinese Medicine Science and Technology Publishing House, Beijing, 2000. Dr. Sun's book represents the first comprehensive Chinese hematology book available in China. This does not mean, however, that treatment manuals of hematological diseases did not exist previously. The main source upon which most ...

A very rare case of acute Graves-Basedow adult disease prompted by a systemic Parvovirus B-19 infection is presented and discussed, on the basis most recent literature evidences in this field. B19 small virus parasiting erythrocytes frequently underestimated clinical practice, when excluding patients with severe hematological diseases.

The WHO classification of tumors of hematopoietic and lymphoid tissues is widely used as a standard for the diagnosis of hematological diseases. However, complicated algorithms developed through the integration of a large amount of laboratory information together with clinical characteristics are employed in most of the diagnostic criteria. Physicians usually have only a limited time to interpr...

Serotonin, or 5-hydroxytryptamine (5-HT), is a well-known neurotransmitter that plays vital roles in neural activities and social behaviors. Clinically, deficiency of serotonin is linked with many psychiatric disorders. Interestingly, a large proportion of serotonin is also produced outside the central nervous system (CNS). There is increasing evidence demonstrating important roles of serotonin...

Reference intervals for common hematological and clinical chemistry parameters constitute an important basis for health care. Moreover, with increasing priority in drug and vaccine development for infectious diseases in Africa, the first priority is the safety evaluation and tolerability of the candidate interventions in healthy populations. To accurately assess health status and address advers...