Skin cancer incidence has increased exponentially over the last three decades. In 2008 skin cancer caused 2280 deaths in the UK, with 2067 due to malignant melanoma. Early diagnosis can prevent mortality, however, conventional treatment requires multiple procedures and increasing treatment times. Second harmonic generation (SHG) imaging could offer diagnosis and demarcation of melanoma borders ...

Second harmonic generation (SHG) in nonlinear optical crystal is well-established technique for the measurement of the pulse-width of ultrafast femtosecond laser pulses. However, only selected nonlinear crystalline materials are suited for this purpose due to the limitations in transparency cut-off, limited phase-matching wavelength range, and large difference between the group velocities of th...

Second-harmonic-generation (SHG) imaging of mouse ovaries ex vivo was used to detect collagen structure changes accompanying ovarian cancer development. Dosing with 4-vinylcyclohexene diepoxide and 7,12-dimethylbenz[a]anthracene resulted in histologically confirmed cases of normal, benign abnormality, dysplasia, and carcinoma. Parameters for each SHG image were calculated using the Fourier tran...

We study the effective second-harmonic generation (SHG) susceptibility in graded metallic films by invoking the local field effects exactly, and further numerically demonstrate that the graded metallic films can serve as a novel optical material for producing a broad structure in both the linear and SHG response and an enhancement in the SHG signal. ocis: 160.4330, 310.6860, 160.4670, 160.4760.

the study examined the effect of women led self help group on micro-financing of farms in isuikwuato local government area of abia state, nigeria. purposive and multistage random sampling technique was employed for collecting data from one hundred and twenty (120) women farmers in women led self help group by using structured interview schedule. the data were analyzed using descriptive statisti...

Renal interstitial fibrosis (IF) is an important pathologic manifestation of disease progression in a variety of chronic kidney diseases (CKD). However, the quantitative and reproducible analysis of IF remains a challenge, especially in experimental animal models of progressive IF. In this study, we compare traditional polarized Sirius Red morphometry (SRM) to novel Second Harmonic Generation (...

BACKGROUND Second Harmonic Generation (SHG) microscopy recently appeared as an efficient optical imaging technique to probe unstained collagen-rich tissues like cornea. Moreover, corneal remodeling occurs in many diseases and precise characterization requires overcoming the limitations of conventional techniques. In this work, we focus on diabetes, which affects hundreds of million people world...

We study the effective second-harmonic generation (SHG) susceptibility in graded metallic films by invoking the local field effects exactly and further numerically demonstrate that graded metallic films can serve as a novel optical material for producing a broad structure in both the linear and the SHG response and an enhancement in the SHG signal.