shiga toxins (stxs) are bacterial virulence factors produced by shigella dysenteriae serotype 1 and escherichia coli strains. stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. additionally, stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. the inflammatory cyto...

Ophiocoma erinaceus Muller &Troschel (Ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. As, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. Saponin extraction was conducted using conventional method such as f...

Abstract Rare cell sorting with magnetic nanoparticles labels (MNPs) has been achieved by the aid of microfluidic chip, which offers an easy processing approach to sort rare cells from a trace original sample. However, its applications have limited in large part due presence some redundant MNPs sorted target affecting purity cells. This paper demonstrates novel cell-sorting chip based on polydi...

background: flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. methods: the cytotoxic effects of three synthesized flavonoid derivatives (k3, k4 and k5) were evaluated against hela , mda-mb -231 and ht-29 cancer cells using mtt assay. results: the results showed that these flavonoids were not...

HIGHLIGHTS Isolate, fractionate and characterize extracts obtained from soursop leaves. Use of emerging green technologies such as microwave-ultrasound hybridization. The contain kaempferol, procyanidins, catechin, quercetin. total ethanolic extract demonstrates cytotoxic effect on HeLa cells.

Poliomyelitis, an acute viral infectious disease caused by poliovirus, still remains a public health problem in developing countries. Despite the global effort to eradicate polio, continuing the polio immunization with a potent and safe vaccine is essential. For accurate vaccine evaluation, three types of cell lines including Hela, Hep2C and Vero were evaluated and compared using two methods of...

Carbon quantum dots assembled with gambogic acid via a π–π stacking interaction for cancer therapy have high drug loading and targeted delivery, which can overcome resistance, short circulation, retention in cells, thereby exhibiting significant inhibitory effect on the growth of HepG2 HeLa cells. This is reported by Jianfeng Wang co-workers article number 2200201.

Conducting cell apoptosis pathways is a novel strategy in cancer treatment. This study aimed to explain that C. botrys essential oil could induce apoptosis and arrest the cell cycle in HeLa cells. Cytotoxic and apoptogenic effects of the essential oil of Jerusalem-oak (Chenopodium botrys L.), which was obtained from the aerial parts of the plant, were evaluated in HeLa cells. Cell viability was...

background & aim:cervical cancer is the most common   female genital cancer and the second most common cancer in women in the   world. since the herbal ingredients have been used for centuries to treat   cancer, purpose of the present study was to determine the cytotoxic   effect of hydroalcoholic extract from satureja bachtiarica bungeon   hela cancer cells line. experimental: hela cells line ...