T lymphocytes that are involved in cellular mediated immunity include two types known as TCD8+ (Cytotoxic T lymphocytes) and TCD4+ (helper T lymphocytes). TCD4+ has four main subtypes, including TH1, TH2, TH17, and Treg Lymphocytes.TH17 lymphocytes play a role in defense against microbes that TH1 and TH2 lymphocytes have not the ability to respond to them. The most important cytokines, which ar...

stem cells from human exfoliated deciduous teeth (shed) have been introduced recently and  possess characteristics similar to  mesenchymal stem  cells (mscs). because of  their convenient accessibility and safety of harvest, shed can be a preferable source for the ever- increasing mscs’ applications. while they are new, their immunoproperties have not been adequately studied. in this study, we ...

systemic lupus erythematosus (sle) is a chronic autoimmune disease which results in damage to various organs. some animal studies have revealed that activation of toll-like receptors (tlrs) is important in the pathogenesis of sle. in the present study, the percentage of different immune cell subsets in 35 sle patients and 38 control subjects was analyzed by flow cytometry. we also assessed the ...

the biological application of nanoparticles (nps) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. the cytotoxicity was evaluated by mtt and ldh assays. the apoptotic effect of free icd-85 and icd-85 nps on hela cells was assessed using caspase-8 colorimetric assay. the mtt assay showed that icd-85 nps could enhance the in-vitro cyt...

Search for novel anticancer compounds from natural sources is a priority goal of cancer biologists. Rhododendron arboreum one the most stately and impressive species. In hilly areas, flowers R. are used treatment chronic diseases. The current study was aimed to evaluate anti-proliferative property on HeLa cells. Crude extract flower prepared using serial extraction procedure with different solv...

chronic  granulomatous  disease (cgd)  is a rare primary immunodeficiency disorder characterized by a greatly increased susceptibility to severe fungal and bacterial infections caused  by  defects  in  nadph   oxidase  of  phagocytic  cells. we  aimed  to  investigate immunophenotype alterations of naïve and memory b cells and b1a cells in peripheral whole blood from iranian patients with cgd. ...

t lymphocytes that are involved in cellular mediated immunity include two types known as tcd8+ (cytotoxic t lymphocytes) and tcd4+ (helper t lymphocytes). tcd4+ has four main subtypes, including th1, th2, th17, and treg lymphocytes.th17 lymphocytes play a role in defense against microbes that th1 and th2 lymphocytes have not the ability to respond to them. the most important cytokines, which ar...

Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results were obtained using lymphocytes from two patients with active cytomegalovirus (CMV) infections and C...

introduction: bleomycin sulfate is a dna damaging agent used in cancer chemotherapy. the effect of this drug on various cell cycle stages might be different, thus inducing different modes of death (apoptotic or mitotic death). the aim of this investigation was to study the effects of bleomycin on human peripheral blood lymphocytes at various cell cycle stages by two different end points (induct...