Nuchal translucency (NT) measurement between 11 and 14 weeks' gestation is an undisputed marker for aneuploidies. When conventional karyotyping is normal, enlarged NT is a strong marker for adverse pregnancy outcome, associated with miscarriage, intrauterine death, congenital heart defects, and numerous other structural defects and genetic syndromes. The risk of adverse outcome is proportional ...

Preconception and prenatal exposure to environmental contaminants may affect future health. Pregnancy early life are critical sensitive windows of susceptibility. The aim this review was summarize current evidence on the toxic effects environment during pregnancy, neonatal period, childhood. Alcohol use is related foetal alcohol spectrum disorders, syndrome being its most extreme form. Smoking ...

Choriocarcinoma is a subtype of gestational trophoblastic disease. It very rare neoplasm, with incidence about 1 case in 40.000 pregnancies. Gestational form choriocarcinoma arises most commonly after abortion, while nongestational develops from pluripotent germ cells. Choricarcinoma highly malignant and chemosensitive type tumor. A 43-year-old patient diagnosed extra uterine pregnancy Septembe...

BACKGROUND The objective of this study was to determine whether there was an association between mothers' light drinking during pregnancy and risk of behavioural problems, and cognitive deficits in their children at age 3 years. METHODS Data from the first two sweeps of the nationally representative prospective UK Millennium Cohort study were used. Drinking patterns during pregnancy and behav...

Studies suggest that children exposed to cigarette smoke in utero are at risk of becoming obese. Few researchers have evaluated the dose-response association between maternal smoking during pregnancy and childhood obesity or whether this association varies by maternal race/ethnicity. The authors obtained retrospective cohort data by linking records from the Pregnancy Nutrition Surveillance Syst...

UNLABELLED BACKGROUND A seasonal effect of month of birth and risk of allergic disease has been suggested by numerous studies. Few studies have directly measured pollen exposures at different points during pregnancy and in early life, and assessed their effects on risk of respiratory disease outcomes. METHODS Pollen exposure was calculated for the first and last 12 weeks of pregnancy and t...

Inherited thrombophilias, suggested to be risk factors for ovarian hyperstimulation syndrome and known to be associated with venous thromboembolism during pregnancy, may also increase the risk for preeclampsia (PE). We describe the case of a 29-year-old woman with primary infertility with no history of thrombosis, hypertension or renal disorders. In her first pregnancy, achieved by frozen embry...

In their review, Esteban-Vasallo et al. (2012) discussed the use of human placenta to evaluate bio markers of exposure to heavy metals. They correctly concluded that the use of placental tissue specimens to assess heavy metal exposure is actually under used. Surprisingly, they did not mention the well-documented relationship between mercury released from mercury-containing dental amalgam fillin...

BACKGROUND Maternal smoking is associated with disturbed cardiorespiratory control in the infant. Despite lacking knowledge of whether the harmful effects of smoking are caused by combustion products in tobacco smoke or by nicotine, it has been argued that nicotine-replacement therapy during pregnancy is safer than smoking. OBJECTIVE The goal of this study was to investigate if the disturbanc...

The effect of heavy metals at environmentally relevant concentrations on couple fecundity has received limited study despite ubiquitous exposure. In 2005-2009, couples (n=501) desiring pregnancy and discontinuing contraception were recruited and asked to complete interviews and to provide blood specimens for the quantification of cadmium (μg L(-1)), lead (μg dL(-1)) and mercury (μg L(-1)) using...