نتایج جستجو برای: heat shock 70kda protein family

تعداد نتایج: 1813013  

2012
Benjamin Gibert Bénédicte Eckel Lydie Fasquelle Maryline Moulin Frantz Bouhallier Vincent Gonin Gregory Mellier Stéphanie Simon Carole Kretz-Remy André-Patrick Arrigo Chantal Diaz-Latoud

Hsp27 belongs to the heat shock protein family and displays chaperone properties in stress conditions by holding unfolded polypeptides, hence avoiding their inclination to aggregate. Hsp27 is often referenced as an anti-cancer therapeutic target, but apart from its well-described ability to interfere with different stresses and apoptotic processes, its role in non-stressed conditions is still n...

Journal: :Molecular Vision 2009
Li-Yun Zhang Gary Hin-Fai Yam Pancy Oi-Sin Tam Ricky Yiu-Kwong Lai Dennis Shun-Chiu Lam Chi-Pui Pang Dorothy Shu-Ping Fan

PURPOSE To investigate the clinical features and molecular basis of inherited cataract-microcornea caused by an alphaA-crystallin gene (CRYAA) mutation in a Chinese family. METHODS A three-generation Chinese family with members having autosomal dominant cataract and microcornea was recruited. Genomic DNA from peripheral blood or buccal swab samples of five affected and five unaffected members...

2017
Zhen-Yi Jia Tong-Yi Shen Wei Jiang Huan-Long Qin

The aim of the present study was to explore the critical genes and molecular mechanisms in pancreatic cancer (PC) cells with glutamine. By analyzing microarray data GSE17632 from the Gene Expression Omnibus database, the DEGs between PC cells treated with glutamine and without glutamine were evaluated. Additionally, function enrichment analyses and protein-protein interaction (PPI) network cons...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2003
Tsuyoshi Harada Iwao Koyama Toshihiko Kasahara David H Alpers Tsugikazu Komoda

We demonstrate a previously unknown regulation for intestinal-type alkaline phosphatase (IAP) as a heat shock protein (HSP). Heat shock to rat intestinal epithelial cells (IEC)-18 at 43 degrees C induced the expression of IAP-I and HSP72 mRNAs time dependently (<60 min) but did not induce expression of IAP-II, tissue nonspecific-type alkaline phosphatase (TNAP), or HSP90 as determined by the RT...

2014
Indra M. Mahajan Miao-Der Chen Israel Muro John D. Robertson Casey W. Wright Shawn B. Bratton

Acute heat shock can induce apoptosis through a canonical pathway involving the upstream activation of caspase-2, followed by BID cleavage and stimulation of the intrinsic pathway. Herein, we report that the BH3-only protein BIM, rather than BID, is essential to heat shock-induced cell death. We observed that BIM-deficient cells were highly resistant to heat shock, exhibiting short and long-ter...

Journal: :Fish & shellfish immunology 2009
Natha J Booth A Lelania Bilodeau-Bourgeois

A study was performed to compare proteomic profiles of channel catfish from families with high and low susceptibility to Edwardsiella ictaluri following an immersion challenge. Total protein was isolated from head kidney samples, collected at 2 and 6h postexposure, and analyzed by 2-D-gel electrophoresis coupled with peptide mass fingerprint analysis by matrix-assisted laser desorption/ionizati...

Journal: :Neuroscience letters 2008
Lia Frenkel Beatriz Dimant Enrique L Portiansky Héctor Maldonado Alejandro Delorenzi

Heat-shock proteins (Hsp) are synthesized in the central nervous system in response to traumas but also after physical exercise and psychophysiological stress. Therefore, an increase in Hsp expression is a good marker of changes in metabolic activity. In the crab Chasmagnathus, a powerful memory paradigm has been established. Memory modulation is possible by water shortage. The brain areas acti...

Journal: :iranian journal of basic medical sciences 0
parvin heidarieh department of microbiology, school of medicine, isfahan university of medical sciences, isfahan, iran hasan shojaei research center for infectious diseases &amp; tropical medicine, alternatively, department of microbiology, school of medicine and, isfahan university of medical sciences, isfahan, iran mohamad mehdi feizabadi department of medical microbiology, tehran university of medical sciences, tehran, iran asghar havaei department of microbiology, school of medicine, isfahan university of medical sciences, isfahan, iran abodolrazagh hashemi department of microbiology, school of medicine, isfahan university of medical sciences, isfahan, iran behrooz ataei iranian research center for infectious diseases, isfahan university of medical sciences, isfahan, iran

objective(s) rapidly growing mycobacteria (rgm) are capable of producing diseases in humans. since mycobacteria vary in their susceptibility, precise identification is critical for adoption of correct drug therapy. the main aim of this study was molecular identification and evaluation of antimicrobial susceptibility pattern of iranian clinically isolated myocbacterium fortuitum. materials and m...

Journal: :Nucleic acids research 1987
B. Dworniczak M. E. Mirault

In all eukaryotes examined so far, hsp70 gene families include cognate genes (hsc70) encoding proteins of about 70 Kd which are expressed constitutively during normal growth and development. We have investigated the structural relationship of heat-inducible and cognate members of the human hsp70 gene family. Among several human genomic clones isolated using Drosophila hsp/hsc70 probes, one cont...

2006
Yong J. Lee William C. Dewey

While studying the quantitative relationship between hyperthermiainduced heat shock proteins (HSPs) and thermotolerance (TT), we ob served that heat induced a family of HSPs, particularly an HSP 70 family, that might be involved in the development of TT. When cells were heated for 10 min at 4S.S°C, they became thermotolerant to a second heat exposure at 45.5°C,with a thermotolerance ratio of ...

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