Previous studies have suggested that the heart may be capable of limited repair and regeneration in response to a focal injury, while other studies indicate that the mammalian heart has no regenerative capacity. To further explore this issue, we performed a series of superficial and transmural myocardial injuries in C57BL/6 and MRL/MpJ adult mice. At defined time intervals following the respect...

Radiation therapy, which is used for the treatment of some cancers, can cause delayed heart damage. In the heart, p53 influences myocardial injury that occurs after multiple types of stress. Here, we demonstrated that p53 functioned in endothelial cells to protect mice from myocardial injury after whole-heart irradiation. Mice with an endothelial cell-specific deletion of p53 succumbed to heart...

Sharp trauma is an injury resulting in wounds on the surface of body by sharp objects. comprosised three forms wounds, namely incised (vulnus scissum), stab punctum), and chopped caesum). Cardiac damage caused to heart which not congenital or degenerative nature but impact/physical collision from outside can reduce change consciousness lead cognitive abilities, physical function, death. In this...

Hypoxic injury to the heart results in cardiac fibrosis that leads to cardiac dysfunction and heart failure. SNAIL1 is a zinc finger transcription factor implicated in fibrosis following organ injury and cancer. To determine if the action of SNAIL1 contributed to cardiac fibrosis following hypoxic injury, we used an endogenous SNAIL1 bioluminescence reporter mice, and SNAIL1 knockout mouse mode...

The severity of ischaemic heart disease is markedly enhanced in type 2 diabetes. We recently reported that complement activation exacerbates I/R injury in the type 2 diabetic heart. The purpose of this study was to isolate and examine MBL pathway activation following I/R injury in the diabetic heart. ZLC and ZDF rats underwent 30 minutes of left coronary artery occlusion followed by 120 minutes...

OBJECTIVE To determine the incidence, risk factors and outcomes of acute kidney injury in children undergoing cardiac surgery for congenital heart disease. METHODS We enrolled 208 patients undergoing cardiac surgery for congenital heart disease during January 2012 to March 2013. Acute kidney injury was defined as per Acute Kidney Injury Network criteria. RESULTS Twenty patients had Acute ki...

Abstract Introduction Cardiac function has been found to decrease within the first 24 hours after burn injury and documented stay depressed for up 72 hours. Cardioprotective drugs such as sildenafil, PJ34, MitoTEMPO, ZLN005 have shown counteract this dysfunction when administered 1 hour before injury. However, there remains limited knowledge on effects of cardioprotective in early phase Methods...

RATIONALE Tissue ischemia/reperfusion (IR) injury underlies several leading causes of death such as heart-attack and stroke. The lack of clinical therapies for IR injury may be partly due to the difficulty of adapting IR injury models to high-throughput screening (HTS). OBJECTIVE To develop a model of IR injury that is both physiologically relevant and amenable to HTS. METHODS AND RESULTS A...

RATIONALE The ability of the adult heart to generate new myocytes after injury is not established. OBJECTIVE Our purpose was to determine whether the adult heart has the capacity to generate new myocytes after injury, and to gain insight into their source. METHODS AND RESULTS Cardiac injury was induced in the adult feline heart by infusing isoproterenol (ISO) for 10 days via minipumps, and ...