The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label, randomized, balanced, multiple-dose, three-period crossover study. Fourteen subjects received t...

BACKGROUND The immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascades. Of late, autoimmune manifestations that appear to be caused by an external adjuvant have been grouped into a complex syndrome referred to as autoimmune/inflammatory syndrome induced by a...

The current study evaluated the relationship between self-report and behavioral measures of impulsivity in 98 young adult male subjects. Principal components analysis of the self-report measures revealed four primary factors: the first demonstrated significant loadings with Eysenck’s Impulsivity and Nonplanning scales and all subscales of the Barratt Impulsivity Scale, the second with Eysenck’s...

A 31-year-old male presented to the emergency room with a sudden onset of blindness and a rash after a five-day history of myalgia, abdominal pain, and fever. The diagnostic approach and the patient's clinical course are presented. Indications for surgical intervention in staphyloccal endocarditis are discussed. Surgical and autopsy findings are reviewed.

The oxytocin receptor gene (OXTR) rs53576A has been associated with autism spectrum disorders (ASDs). A smaller hypothalamic volume has been reported in healthy male A-allele carriers than in male GG homozygotes and in patients with ASDs than in healthy controls. These findings prompt the hypothesis that male AA homozygotes may have weaker hypothalamic functional connectivity when compared to m...

The antioxidant properties of vitamin C may be involved in the prevention of cancer. The correlation between dietary vitamin C intake as estimated by a dietary questionnaire and plasma ascorbic acid (AA) was examined in 68 nonsmoking male volunteers aged 30-59 years. Determinants of plasma AA as well as interrelationships between various antioxidants in plasma were also explored. The determinan...

BACKGROUND Dobutamine stress echocardiography is used to investigate a wide variety of heart diseases in humans. Dobutamine stress echocardiography has also been used in animal models of heart disease despite the facts that the normal response of healthy rat hearts to this type of pharmacological stress testing is unknown. This study was performed to assess this normal response. METHODS 15 no...

STUDY OBJECTIVE Orexin-A is hypothesized to promote wakefulness, and we examined whether cerebrospinal fluid (CSF) orexin-A levels are higher during the waking period in man. DESIGN Within-subjects, repeated-measures design with balanced ordering of sampling at approximately 5 AM and 5 PM. PARTICIPANTS Eight healthy young males. MESUREMENTS: CSF orexin-A levels and standard polysomnography....

Infection with pneumocystis carinii and cytomegalovirus was found in a young male suspected of having miliary tuberculosis. Problems of diagnosis and predisposing factors for these infections in the patient are discussed. The patient's clinical course and management are reviewed. Autopsy findings are presented. Alternative modes of therapy are considered.

Dear Editor, Upper extremity deep vein thrombosis (UEDVT) refers to thrombosis of the subclavian (18% to 69%), axillary (5% to 42%) or brachial vein (4% to 13%).1 It accounts for 4% to 10% of all cases of deep vein thrombosis1 and can result in pulmonary embolism (PE) or post-thrombotic syndrome (PTS) of the arm and even death in severe cases.1 We describe a case of UEDVT in a healthy young Chi...