This brief review discusses the behavioral consequences of two pharmacologically selected lines of rats. Flinders Sensitive (FSL) and Flinders Resistant (FRL) Lines of rats were selected on the basis of differential hypothermic and behavioral responses to the anticholinesterase, diisopropylfluorophosphate (DFP). FSL rats are more sensitive to the hypothermic effects of cholinergic, serotonergic...

Soluble MUC1 (sMUC1) levels are elevated in many MUC1(+) cancers. We and others have shown that MUC1 is expressed on multiple myeloma (MM) plasma cells and B cells. In this study, we measured sMUC1 levels in bone marrow (BM) plasma from 71 MM patients and 21 healthy donors (HDs), and in peripheral blood (PB) plasma from 42 MM patients and 13 HDs using an immunoassay that detects the CA27.29 epi...

Recent research on answer set programming (ASP) systems, has mainly focused on solving NP problems more efficiently. Yet, disjunctive logic programs allow for expressing every problem in the complexity classes Σ 2 and Π P 2 . These classes are widely believed to be strictly larger than NP, and several important AI problems, like conformant and conditional planning, diagnosis and more are locate...

The role of CD4(+) T cells in the pathogenesis of aplastic anemia (AA) is not well characterized. We investigate CD4(+) T-cell subsets in AA. Sixty-three patients with acquired AA were studied. Th1 and Th2 cells were significantly higher in AA patients than in healthy donors (HDs; P = .03 and P = .006). Tregs were significantly lower in patients with severe AA than in HDs (P < .001) and patient...

Background—The first Sibrafiban Versus Aspirin to Yield Maximum Protection From Ischemic Heart Events Post–Acute Coronary Syndromes (SYMPHONY) trial showed no benefit of 2 doses of sibrafiban over aspirin for secondary prevention after acute coronary syndromes. In 2nd SYMPHONY, we compared low-dose sibrafiban plus aspirin (LDS1A), high-dose sibrafiban (HDS), and aspirin alone. Methods and Resul...

This paper presents a hybrid approximate dynamic programming (ADP) method for a hybrid dynamic system (HDS) optimal control problem, that occurs in many complex unmanned systems which are implemented via a hybrid architecture, regarding robot modes or the complex environment. The HDS considered in this paper is characterized by a well-known three-layer hybrid framework, which includes a discret...

A 13-week dermal repeat-dose toxicity study was conducted with hydrodesulfurized (HDS) kerosene, a test material that also met the commercial specifications for aviation turbine fuel (jet A). The objectives were to assess the potential for target organ toxicity and neurotoxicity. The HDS kerosene was applied to the shaved backs of Sprague-Dawley CD rats, 12/sex/group, 6 h/d, 5 d/wk in doses of ...

PURPOSE To examine the onset and outcome of ipilimumab-related hypophysitis and the response to treatment with systemic high-dose corticosteroids (HDS). EXPERIMENTAL DESIGN Twenty-five patients who developed ipilimumab-related hypophysitis were analyzed for the incidence, time to onset, time to resolution, frequency of resolution, and the effect of systemic HDS on clinical outcome. To calcula...

Insertion/deletion (I/D) polymorphisms of the gene encoding angiotensin converting enzyme (ACE) are a controversial risk factor for heart diseases (HDs). ACE I/D polymorphism has been reported to be associated with various cardiovascular diseases. However, some studies have presented conflicting results. In this study, we aim to explore the association between ACE I/D polymorphisms and the risk...

Reduction of harmful emissions in the combustion of fossil fuels imposes tighter specifications limiting the sulfur content of fuels. Hydrodesulfurization (HDS) is a key process inmost petroleumrefineries inwhich the sulfur ismostly eliminated. Themodeling and simulation of the HDS process are necessary for a better understanding of the process operation; it is also a requirement to optimize pr...