The pharmacokinetic characteristics of piperacillin sodium were studied in five volunteers undergoing on-line hemodiafiltration (HDF). The subjects were given 2 g of piperacillin sodium intravenously over 1 min and placed on on-line HDF for 4 h starting at 60 min after the piperacillin infusion. Noncompartmental models were employed for estimation of the pharmacokinetic parameters, and intradia...

We derive simple empirical color-redshift relations for z < ∼ 4 galaxies in the Hubble Deep Field (HDF) using a linear function of three photometric colors (U − B, B − V , V − I). The dispersion between the estimated redshifts and the spectroscopically observed ones is small for relations derived in several separate color regimes; the dispersions range from σ z ≃ 0.03 to 0.1 for z < ∼ 2 galaxie...

The production of matrix metalloproteinases (MMP) by UV-irradiated skin fibroblasts and the degradation of the extracellular matrix by these enzymes is known as one of the main causes of photoaging. Recently, the Fisher group showed that MMP expression is mainly regulated by members of the mitogen-activated protein kinase family such as extracellular signal-regulated kinase, c-Jun amino-termina...

BACKGROUND Skin hyperpigmentation in end-stage renal disease (ESRD) patients has been attributed to the accumulation of middle-molecular-weight (MMW) substances. Although an MMW mechanism suggests that hyperpigmentation may be improved by high-flux haemodialysis (HF-HD) and haemodiafiltration (HDF), this possibility has not been explored. In the present study, we investigated the impact of diff...

BACKGROUND Treatment modalities of renal replacement therapy differ in their diffusive and convective mass transfer characteristics. It was the goal of this study to clarify whether an increase in convective mass transfer as performed with haemofiltration (HF) and haemodiafiltration (HDF) in comparison with high-flux haemodialysis (HD) is associated with an alteration in procoagulatory activity...

BACKGROUND Although the capability of extracorporeal treatments after administration of contrast media to prevent radiocontrast-induced nephropathy is controversial, haemodialysis is performed in many institutions after radiographic procedures. There are conflicting reports on the efficacy of different dialysers and treatment modalities to remove contrast media. METHODS We compared the contra...

Clinical frailty in the elderly is defined by a composite measure of functional psychomotor decline. Herein, we develop concept haemodynamic (HDF), state increased predisposition to disease prevalent and characterised impairment network compensatory responses governing defence circulatory volume adaptive function. We review factors predisposing HDF, with focus on impaired capacity sustain total...