multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by a complex immune response. because of the complex nature of ms pathogenesis, a panel of biomarkers derived from different platforms will be required to reflect disease-related alterations. monitoring and evaluation of molecules associated with the pathogenesis of the disease would provide useful ...

Background: The administration of the third (or booster) dose COVID-19 vaccine is important in maintaining protection against SARS-CoV-2 infection or severity disease. In Indonesia, health care workers (HCWs) are among first to receive a booster vaccine. this study, we evaluated antibody response and adverse events following heterologous using mRNA-1273 HCWs that were fully vaccinated with inac...

Background: Many recent epidemiological studies have shown that epileptic patients are more likely suffer from depression, anxiety, and irritability. However, the cellular mechanisms of epilepsy-induced psychotic behaviors are not fully elucidated. Neurotrophin receptors have been suggested to be involved in epilepsy and also in psychiatric disorders. Up-regulation of p75NTR expression and acti...

Hypercholesterolemia is the primary risk factor for cardiovascular disease (CVD). Recent studies reported that stimulation of transintestinal cholesterol excretion (TICE), a nonbiliary excretion, can be strategy preventing CVD. Black elderberry (Sambucus nigra) has been to reduce CVD via its antioxidant, anti-inflammatory, and hypocholesterolemic effects. However, little known about role black ...

In situ hybridization experiments were performed in rat brain sections from normal and 6-hydroxydopamine-treated rats in order to map and identify the neurons expressing the D1 receptor gene in the striatum and the substantia nigra. Procedures of combined in situ hybridization, allowing the simultaneous detection of two mRNAs in the same section or in adjacent sections, were used to characteriz...

A specific luteinizing hormone receptor (LHR) mRNA binding protein (LRBP) has been identified and purified. This LH receptor mRNA binding protein selectively binds to the polypyrimidine rich bipartite sequence in the coding region of the LHR mRNA and accelerates its degradation. In response to preovulatory LH surge, the LH receptor expression in the ovary undergoes downregulation by accelerated...