نتایج جستجو برای: hbv escape mutants
تعداد نتایج: 119001 فیلتر نتایج به سال:
HBx mutations (T1753V, A1762T, G1764A, and T1768A) are frequently observed in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Aberrant activation of the Wnt/β-catenin signaling pathway is involved in the development of HCC. However, activation of the Wnt/β-catenin signaling pathway by HBx mutants has not been studied in hepatoma cells or HBV-associated HCC samples. In this study...
result, it has a much higher error rate than DNA viral transcriptases, as it replicates through a RNA intermediate. HBV DNA is thus often present in quasi-species in an individual. One or more species may be favourably selected by factors such as host immune clearance and use of antiviral drugs.1 HBV variation plays an important role in HBV genotypes and drug-resistant mutations. It is clinical...
In China, HIV-1-infected patients typically receive antiretroviral therapy (ART) that includes lamivudine (3TC) as a reverse-transcriptase inhibitor (RTI) (ART-3TC). Previous studies from certain developed countries have shown that, in ART-3TC, 3TC-resistant HBV progressively emerges at an annual rate of 15-20% in patients coinfected with HIV-1 and HBV. This scenario in China warrants investiga...
The four main approaches to immunisation against hepatitis B are: vaccination of high risk babies; universal adolescent immunisation; universal infant immunisation; and vaccination of everybody. Universal antenatal screening would permit identification of carrier mothers and immunisation oftheir babies. Vaccination of adolescents would provide protection close to the time when risk of exposure ...
Hepatitis B virus (HBV) causes acute and chronic hepatitis B (CHB). Due to its error-prone replication via reverse transcription, HBV can rapidly evolve variants that escape vaccination and/or become resistant to CHB treatment with nucleoside/nucleotide analogs (NAs). This is particularly problematic for the first generation NAs lamivudine and adefovir. Though now superseded by more potent NAs,...
The four main approaches to immunisation against hepatitis B are: vaccination of high risk babies; universal adolescent immunisation; universal infant immunisation; and vaccination of everybody. Universal antenatal screening would permit identification of carrier mothers and immunisation oftheir babies. Vaccination of adolescents would provide protection close to the time when risk of exposure ...
Abstract Background: Investigators were suspicious of tyrosine-methionine-aspartate-aspartate (YMDD) mutations occurred only in patients who were treated by lamivudine. However, YMDD mutations of hepatitis B virus gene (HBV DNA) in patients with chronic hepatitis B (CHB) untreated with antiviral medicines was reported in some studies. The aim of this study was to evaluate YMDD mutations in Ira...
Viruses employ various means to evade immune detection. Reduction of CD8(+) T cell epitopes is one of the common strategies used for this purpose. Hepatitis B virus (HBV), a member of the Hepadnaviridae family, has four open reading frames, with about 50% overlap between the genes they encode. We computed the CD8(+) T cell epitope density within HBV proteins and the mutations within the epitope...
BACKGROUND We aimed to elucidate the impact of hepatitis B virus (HBV) precore/core gene mutations on spontaneous hepatitis B e antigen (HBeAg) seroconversion, HBV biosynthesis, and the human immune responses in chronic HBV-infected patients. METHODS We analyzed the HBV precore/core gene sequences by cloning method in 33 chronic HBV-infected patients during the inflammatory phase before spo...
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