Sporadic evidence suggests Notch is involved in cell adhesion. However, the underlying mechanism is unknown. Here I have investigated an epithelial remodeling process in the Drosophila eye in which two primary pigment cells (PPCs) with a characteristic 'kidney' shape enwrap and eventually isolate a group of cone cells from inter-ommatidial cells (IOCs). This paper shows that in the developing D...

Multiple hemangioblastomas (HBs) of the central nervous system (CNS) and retina are associated with von HippelLindau disease (VHL) and also predispose individuals to renal cell carcinomas and visceral cysts. In VHL, microsurgery or radiosurgery cannot prevent new HBs from arising in the CNS or coagulation of retinal HBs. Multiple but thus far asymptomatic HBs pose a therapeutic problem. IFNa-2a...

Abstract Malignant transformation of gastrointestinal stromal tumors (GISTs) is correlated with poor prognosis; however, the underlying biological mechanism not well understood. In present study, low-risk (LR) GISTs, GISTs categorized as high-risk based on tumor size (HBS), and mitotic rate (HBM) were collected for RNA sequencing. Candidate hub lncRNAs selected by Oncomine analysis. Expression ...

Hepatitis B virus (HBV) infection continues to be a major health problem worldwide. The large-scale immunization programs for persons in high-risk groups, newborns, and adolescents have greatly reduced the incidence of new infection, but the ∼400 million HBV carriers with HBV surface antigen (HBsAg) in the blood remain a burden that will dwindle only within decades. Furthermore, an unknown dise...

HBS is a handheld system for noninvasive breast cancer detection based on frequency domain photon migration. It performs broadband modulation on near-infrared laser intensity and derives the scattering and absorption coefficients from phase and amplitude measurements. Recovered optical properties of phantom and tissue by HBS clearly show the difference between normal and cancer tissue. Measurem...

Sickle cell disease is a hereditary, autosomal recessive pathology caused by the replacement of adenine thymin in position 6 beta globin gene, producing anomalous hemoglobin (hemoglobin S- HbS). It characterized chronic inflammatory state with hemolytic anemia and vaso-occlusive phenomena occurs when HbS gene homozygosis (SS) or heterozygosis, association other variant hemoglobins (SD, SC, SE) ...

It has been postulated that host immune defects are responsible for the development and persistence of the hepatitis B surface antigen (HBsAg) carrier state. The nature of these defects is unknown, but the absence of a readily detectable antibody response to HBsAg (anti-HBs) may be important. The synthesis of both anti-HBs and antibody to hepatitis B core antigen (anti-HBc) in cultures containi...

Phosphate buffer saline (PBS) has numerous biological and pharmaceutical applications. Hank buffer salt (HBS) has been used as a medium for tissue culture applications. This research study was aimed to investigate the influence of Mr. Trivedi’s biofield energy treatment on physicochemical properties of the PBS and HBS. The study was executed in two group’s i.e. control and treated. The control ...