IntroductionLysozyme-associated nephropathy (LyN), a rare cause of kidney injury in patients with chronic myelomonocytic leukemia (CMML), has not been well described to date. We report the clinicopathologic spectrum LyN from multi-institutional series.MethodWe identified 37 native biopsies and retrospectively obtained data.ResultsThirty-seven had median age 74 years included 78% males. Their mo...

A twenty-year-old carpenter died suddenly and unexpectedly nine years after surgical treatment of coarctation of the aorta. Both before and after surgery he had paroxysmal atrial fibrillation, T wave inversions in the ECG and persisting cardiac hypertrophy. At postmortem examination there was focal fibromuscular dysplasia narrowing the sinus node artery, but other small coronary arteries were n...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...

BACKGROUND The clinical significance of progesterone receptor (PgR) expression in estrogen receptor-negative (ER-) breast cancer is controversial. Herein, we systemically investigate the clinicopathologic features, molecular essence, and endocrine responsiveness of ER-/PgR+/HER2- phenotype. METHODS Four study cohorts were included. The first and second cohorts were from the Surveillance, Epid...